Dialkylgallium alkoxides – a tool for facile and stereoselective synthesis of PLA–drug conjugates

Herein, a method for the synthesis of PLA-(β-blocker) conjugates with a tunable stereostructure of the PLA fragment is demonstrated using stereoselective [R2Ga(μ-β-blocker)]2 catalysts and [R2Ga(μ-OR)]2/H-(β-blocker) catalytic systems for the ring-opening polymerisation (ROP) and immortal ring-opening polymerisation (iROP) of racemic lactide (rac-LA), respectively.