Artykuł w czasopiśmie
Brak miniatury
Licencja

CC-BYCC-BY - Uznanie autorstwa

Personalized prediction of the secondary oocytes number after ovarian stimulation: A machine learning model based on clinical and genetic data

Autor
Jakóbkiewicz-Banecka, Joanna
Kloska, Anna
Drzyzga, Damian
Drzewiecka, Dominika
Zieleń, Marcin
Wygocki, Piotr
Kotlarz, Marta
Mickiewicz, Małgorzata
Pukszta, Sebastian
Zieliński, Krystian
Data publikacji
2023
Abstrakt (EN)

Controlled ovarian stimulation is tailored to the patient based on clinical parameters but estimating the number of retrieved metaphase II (MII) oocytes is a challenge. Here, we have developed a model that takes advantage of the patient’s genetic and clinical characteristics simultaneously for predicting the stimulation outcome. Sequence variants in reproduction-related genes identified by next-generation sequencing were matched to groups of various MII oocyte counts using ranking, correspondence analysis, and self-organizing map methods. The gradient boosting machine technique was used to train models on a clinical dataset of 8,574 or a clinical-genetic dataset of 516 ovarian stimulations. The clinical-genetic model predicted the number of MII oocytes better than that based on clinical data. Anti-Müllerian hormone level and antral follicle count were the two most important predictors while a genetic feature consisting of sequence variants in the GDF9, LHCGR, FSHB, ESR1, and ESR2 genes was the third. The combined contribution of genetic features important for the prediction was over one-third of that revealed for anti-Müllerian hormone. Predictions of our clinical-genetic model accurately matched individuals’ actual outcomes preventing over- or underestimation. The genetic data upgrades the personalized prediction of ovarian stimulation outcomes, thus improving the in vitro fertilization procedure.

Dyscyplina PBN
informatyka
Czasopismo
PLoS Computational Biology
Tom
19
Zeszyt
4
Strony od-do
e1011020: 1-18
ISSN
1553-734X
Data udostępnienia w otwartym dostępie
2023-04-27
Licencja otwartego dostępu
Uznanie autorstwa