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Native Structure-Based Peptides as Potential Protein–Protein Interaction Inhibitors of SARS-CoV-2 Spike Protein and Human ACE2 Receptor

Autor
Marzec, Ewa
Poznański, Jarosław
Winiewska-Szajewska, Maria
Zielenkiewicz, Piotr
Odolczyk, Norbert
Data publikacji
2021
Abstrakt (EN)

Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) is a positive-strand RNA virus that causes severe respiratory syndrome in humans, which is now referred to as coronavirus disease 2019 (COVID-19). Since December 2019, the new pathogen has rapidly spread globally, with over 65 million cases reported to the beginning of December 2020, including over 1.5 million deaths. Unfortunately, currently, there is no specific and effective treatment for COVID-19. As SARS-CoV-2 relies on its spike proteins (S) to bind to a host cell-surface receptor angiotensin-converting enzyme-2(ACE2), and this interaction is proved to be responsible for entering a virus into host cells, it makes an ideal target for antiviral drug development. In this work, we design three very short peptides based on the ACE2 sequence/structure fragments, which may effectively bind to the receptor-binding domain (RBD) of S protein and may, in turn, disrupt the important virus-host protein–protein interactions, blocking early steps of SARS-CoV-2 infection. Two of our peptides bind to virus protein with affinity in nanomolar range, and as very short peptides have great potential for drug development.

Słowa kluczowe EN
SARS-CoV-2
COVID-19
inhibitors of protein–protein interactions
peptides
drug design
coronavirus
angiotensin-converting enzyme-2
ACE2
Dyscyplina PBN
nauki biologiczne
Czasopismo
Molecules
Tom
26
Zeszyt
8
Strony od-do
2157
ISSN
1420-3049
Data udostępnienia w otwartym dostępie
2021-04-09
Licencja otwartego dostępu
Uznanie autorstwa