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Nuclear imaging for immune cell tracking in vivo – Comparison of various cell labeling methods and their application

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cris.lastimport.scopus2024-02-12T20:32:55Z
dc.abstract.enThere is currently great interest in the development of cell-based therapies, particularly those focused onthe idea of exploiting systemically administered immune cells for therapeutic purposes in cancer (e.g.,CAR-T and CAR-NK cells). The ability to monitor the fate of cellsin vivoafter administration is vital forthe assessment of therapeutic outcomes of immune cell-based therapies both in preclinical researchand clinical practice. In this context, imaging techniques, which allow for noninvasive and real-time mon-itoring of the distribution and long-term viability of the adoptively transferred immune cells in the tissueof interest, are of paramount importance. Among clinically relevantin vivoimaging modalities, thenuclear imaging techniques, comprising planar scintigraphy, SPECT, and PET, are considered to be of piv-otal importance toin vivocell tracking and designing optimal treatment strategies for cell-based thera-pies. This review paper focuses on nuclear imaging and its role in the evaluation of immune cell-basedtherapies’ effectiveness - tracking cells and their ability to home to the target tissue. We compare differ-ent types of radiotracers, outline various ways of immune cell labeling, and provide the latest examplesfor the use of nuclear imaging techniques both in preclinical studies and clinical settings.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDomańska, Anita
dc.contributor.authorRygiel, Tomasz P.
dc.contributor.authorKról, Magdalena
dc.contributor.authorRogulski, Zbigniew
dc.contributor.authorKucharzewska, Paulina
dc.contributor.authorKiraga, Łukasz
dc.contributor.authorCheda, Łukasz
dc.contributor.authorBoffi, Alberto
dc.contributor.authorPaisey, Stephen
dc.date.accessioned2024-01-25T14:01:36Z
dc.date.available2024-01-25T14:01:36Z
dc.date.copyright2021-07-07
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.versionFINAL_PUBLISHED
dc.description.volume445
dc.identifier.doi10.1016/J.CCR.2021.214008
dc.identifier.issn0010-8545
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/114053
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0010854521002824?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCoordination Chemistry Reviews
dc.relation.pagesart.no. 214008
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enNuclear imaging
dc.subject.enSPECT
dc.subject.enPET
dc.subject.enRadiotracersImmune cell tracking
dc.subject.enCell labeling
dc.titleNuclear imaging for immune cell tracking in vivo – Comparison of various cell labeling methods and their application
dc.typeJournalArticle
dspace.entity.typePublication