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Aquaporin graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination

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dc.abstract.enThe aquaporin superfamily of hydrophobic integral membrane proteins constitutes water channels essential to the movement of water across the cell membrane, maintaining homeostatic equilibrium. During the passage of water between the extracellular and intracellular sides of the cell, aquaporins act as ultra-sensitive filters. Owing to their hydrophobic nature, aquaporins self-assemble in phospholipids. If a proper choice of lipids is made then the aquaporin biomimetic membrane can be used in the design of an artificial kidney. In combination with graphene, the aquaporin biomimetic membrane finds practical application in desalination and water recycling using mostly Escherichia coli AqpZ. Recently, human aquaporin 1 has emerged as an important biomarker in renal cell carcinoma. At present, the ultra-sensitive sensing of renal cell carcinoma is cumbersome. Hence, we discuss the use of epitopes from monoclonal antibodies as a probe for a point-of-care device for sensing renal cell carcinoma. This device works by immobilizing the antibody on the surface of a single-layer graphene, that is, as a microfluidic device for sensing renal cell carcinoma.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorAltaee, Ali
dc.contributor.authorJakowiecki, Jakub
dc.contributor.authorEswara, Jairam R.
dc.contributor.authorAjayan, Pulickel M.
dc.contributor.authorFilipek, Sławomir
dc.contributor.authorSharif, Adel O.
dc.contributor.authorLi, Pingzuo
dc.contributor.authorRenugopalakrishnan, Venkatesan
dc.contributor.authorSztyler, Agnieszka
dc.contributor.authorBarathiraja, Natarajan
dc.contributor.authorRaman, Karthik
dc.contributor.authorRamakrishna, Seeram
dc.date.accessioned2024-01-24T16:55:20Z
dc.date.available2024-01-24T16:55:20Z
dc.date.copyright2018-04-20
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number3
dc.description.versionFINAL_PUBLISHED
dc.description.volume8
dc.identifier.doi10.1098/RSFS.2017.0066
dc.identifier.issn2042-8898
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/101059
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInterface Focus
dc.relation.pagesart.no. 20170066
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enAquaporin
dc.subject.enDesalination
dc.subject.enGraphene
dc.subject.enMembrane
dc.subject.enPoint-of-care
dc.subject.enWater recycling
dc.titleAquaporin graphene interface: relevance to point-of-care device for renal cell carcinoma and desalination
dc.typeJournalArticle
dspace.entity.typePublication