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Magnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice

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dc.abstract.enChronic Mg2+ deficiency is the underlying cause of a broad range of health dysfunctions. As 25% of body Mg2+ is located in the skeletal muscle, Mg2+ transport and homeostasis systems (MgTHs) in the muscle are critical for whole-body Mg2+ homeostasis. In the present study, we as-sessed whether Mg2+ deficiency alters muscle fiber characteristics and major pathways regulating muscle physiology. C57BL/6J mice received either a control, mildly, or severely Mg2+-deficient diet (0.1%; 0.01%; and 0.003% Mg2+ wt/wt, respectively) for 14 days. Mg2+ deficiency slightly decreased body weight gain and muscle Mg2+ concentrations but was not associated with detectable variations in gastrocnemius muscle weight, fiber morphometry, and capillarization. Nonetheless, muscles exhibited decreased expression of several MgTHs (MagT1, CNNM2, CNNM4, and TRPM6). Moreover, TaqMan low-density array (TLDA) analyses further revealed that, before the emergence of major muscle dysfunctions, even a mild Mg2+ deficiency was sufficient to alter the expression of genes critical for muscle physiology, including energy metabolism, muscle regeneration, proteostasis, mitochondrial dynamics, and excitation–contraction coupling.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGueugneau, Marine
dc.contributor.authorCoudy-Gandilhon, Cécile
dc.contributor.authorBayle, Dominique
dc.contributor.authorMaier, Jeanette A.
dc.contributor.authorBéchet, Daniel
dc.contributor.authorMazur, André
dc.contributor.authorPalinska-Saadi, Adriana
dc.contributor.authorMaj-Żurawska, Magdalena
dc.contributor.authorZocchi, Monica
dc.contributor.authorCastiglioni, Sara
dc.date.accessioned2024-01-25T05:30:51Z
dc.date.available2024-01-25T05:30:51Z
dc.date.copyright2021-06-24
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number7
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3390/NU13072169
dc.identifier.issn2072-6643
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/111670
dc.identifier.weblinkhttps://www.mdpi.com/2072-6643/13/7/2169/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNutrients
dc.relation.pages2169
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enMagnesium
dc.subject.enMagnesium transporters
dc.subject.enSkeletal muscle
dc.subject.enTranscriptome
dc.titleMagnesium Deficiency Alters Expression of Genes Critical for Muscle Magnesium Homeostasis and Physiology in Mice
dc.typeJournalArticle
dspace.entity.typePublication