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Three-Dimensional Printable Conductive Semi-Interpenetrating Polymer Network Hydrogel for Neural Tissue Applications

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cris.lastimport.scopus2024-02-12T20:32:05Z
dc.abstract.enIntrinsically conducting polymers (ICPs) are widely used to fabricate biomaterials; their application in neural tissue engineering, however, is severely limited because of their hydrophobicity and insufficient mechanical properties. For these reasons, soft conductive polymer hydrogels (CPHs) are recently developed, resulting in a water-based system with tissue-like mechanical, biological, and electrical properties. The strategy of incorporating ICPs as a conductive component into CPHs is recently explored by synthesizing the hydrogel around ICP chains, thus forming a semi-interpenetrating polymer network (semi-IPN). In this work, a novel conductive semi-IPN hydrogel is designed and synthesized. The hybrid hydrogel is based on a poly(N-isopropylacrylamide-co-N-isopropylmethacrylamide) hydrogel where polythiophene is introduced as an ICP to provide the system with good electrical properties. The fabrication of the hybrid hydrogel in an aqueous medium is made possible by modifying and synthesizing the monomers of polythiophene to ensure water solubility. The morphological, chemical, thermal, electrical, electrochemical, and mechanical properties of semi-IPNs were fully investigated. Additionally, the biological response of neural progenitor cells and mesenchymal stem cells in contact with the conductive semi-IPN was evaluated in terms of neural differentiation and proliferation. Lastly, the potential of the hydrogel solution as a 3D printing ink was evaluated through the 3D laser printing method. The presented results revealed that the proposed 3D printable conductive semi-IPN system is a good candidate as a scaffold for neural tissue applications.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorZembrzycki, Krzysztof
dc.contributor.authorKowalewski, Tomasz
dc.contributor.authorLanzi, Massimiliano
dc.contributor.authorFiorelli, Roberto
dc.contributor.authorSanai, Nader
dc.contributor.authorPierini, Filippo
dc.contributor.authorJezierska-Woźniak, Katarzyna
dc.contributor.authorMaksymowicz, Wojciech
dc.contributor.authorCamposeo, Andrea
dc.contributor.authorPisignano, Dario
dc.contributor.authorUrbanek, Olga
dc.contributor.authorGrippo, Valentina
dc.contributor.authorRinoldi, Chiara
dc.contributor.authorNakielski, Paweł
dc.date.accessioned2024-01-26T10:52:19Z
dc.date.available2024-01-26T10:52:19Z
dc.date.copyright2021-06-21
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number7
dc.description.versionFINAL_PUBLISHED
dc.description.volume22
dc.identifier.doi10.1021/ACS.BIOMAC.1C00524
dc.identifier.issn1525-7797
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123360
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofBiomacromolecules
dc.relation.pages3084-3098
dc.rightsCC-BY-NC-ND
dc.sciencecloudnosend
dc.titleThree-Dimensional Printable Conductive Semi-Interpenetrating Polymer Network Hydrogel for Neural Tissue Applications
dc.typeJournalArticle
dspace.entity.typePublication