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Dostęp zamkniętyRecent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective
| cris.lastimport.scopus | 2024-02-12T20:27:36Z |
| dc.abstract.en | Poor water solubility, off-target toxicity, and small therapeutic window are among major obstacles for the development of drug products. Redox-responsive drug delivery nanoplatforms not only overcome the delivery and pharmacokinetic pitfalls observed in conventional drug delivery, but also leverage the site-specific delivery properties. Cleavable diselenide and disulfide bonds in the presence of elevated reactive oxygen species (ROS) and glutathione concentration are among widely used stimuli-responsive bonds to design nanocarriers. This review covers a wide range of redox-responsive chemical structures and their properties for designing nanoparticles aiming controlled loading, delivery, and release of hydrophobic anticancer drugs at tumor site. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Maćkiewicz, Marcin |
| dc.contributor.author | Mollazadeh, Shirin |
| dc.contributor.author | Yazdimamaghani, M. |
| dc.date.accessioned | 2024-01-25T18:48:03Z |
| dc.date.available | 2024-01-25T18:48:03Z |
| dc.date.issued | 2021 |
| dc.description.finance | Publikacja bezkosztowa |
| dc.description.volume | 118 |
| dc.identifier.doi | 10.1016/J.MSEC.2020.111536 |
| dc.identifier.issn | 0928-4931 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/117958 |
| dc.identifier.weblink | https://api.elsevier.com/content/article/PII:S0928493120334548?httpAccept=text/xml |
| dc.language | eng |
| dc.pbn.affiliation | chemical sciences |
| dc.relation.ispartof | Materials Science and Engineering C |
| dc.relation.pages | 111536 |
| dc.rights | ClosedAccess |
| dc.sciencecloud | nosend |
| dc.subject.en | Cleavable linkers |
| dc.subject.en | Drug delivery |
| dc.subject.en | Nanomedicine |
| dc.subject.en | Nanoparticle |
| dc.subject.en | Redox-responsive |
| dc.title | Recent advances in the redox-responsive drug delivery nanoplatforms: A chemical structure and physical property perspective |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |