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Regulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy

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dc.abstract.enAbstractMultiple factors underlie the pathophysiology of hypertension, involving endothelial dysregulation, vascular smooth muscle dysfunction, increased oxidative stress, sympathetic nervous system activation and altered renin -angiotensin -aldosterone regulatory activity. A class of non-coding RNA called microRNA, consisting of 17–25 nucleotides, exert regulatory function over these processes. This paper summarizes the currently available data from preclinical and clinical studies on miRNA in the development of hypertension as well as the impact of anti-hypertensive treatment on their plasma expression. We present microRNAs’ characteristics, their biogenesis and role in the regulation of blood pressure together with their potential diagnostic and therapeutic application in clinical practice.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKuch, Marek
dc.contributor.authorKlimczak, Dominika
dc.contributor.authorJażdżewski, Krystian
dc.date.accessioned2024-01-25T19:09:41Z
dc.date.available2024-01-25T19:09:41Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.identifier.doi10.3109/08037051.2016.1167355
dc.identifier.issn0803-7051
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/118234
dc.pbn.affiliationmedical sciences
dc.relation.ispartofBlood Pressure
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleRegulatory mechanisms in arterial hypertension: role of microRNA in pathophysiology and therapy
dc.typeJournalArticle
dspace.entity.typePublication