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Synthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application

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cris.lastimport.scopus2024-02-12T20:32:28Z
dc.abstract.enCommendable efforts have been gingered towards the fight against cancer. Nevertheless, it remains a major public health concern due to its predominant cause of death globally. Given this, we synthesized two different nanoparticles, Sr2+ and Gd3+ doped magnetite for magnetic hyperthermia and drug delivery application. Based on the characterization, the diffractogram shows that only one phase related to magnetite with a crystallite size of 10 nm was formed. TEM images revealed nanoparticles of spherical shapes of approximately 12 nm. There is no difference in magnetic saturation of the as-received synthesized samples (Fe3O4@Sr and Fe3O4@Gd), while the BET-specific surface area of Fe3O4@Gd is 8 m2 g−1 higher than Fe3O4@Sr. The heat generation in alternating magnetic field (the magnetic hyperthermia) of Fe3O4@Sr functionalized with citric acid and loaded with 5- fluorouracil (Fe3O4@Sr@CA@5-flu) is slower than Fe3O4@Gd@CA@5-flu. The specific absorption rate (SAR) of Fe3O4@Gd@CA@5-flu, 112.0 ± 10.4 W g−1 was found to be higher than that of Fe3O4@Sr@CA@5-flu. The thermogram shows that 11% of the drug was successfully loaded on Fe3O4@Gd@CA@5-flu. The release of the antitumor drug by the synthesized nanoparticle drug carriers for ovarian cancer (SKOV-3 cells) therapy showed that more than 50% of the cancer cell’s viability was reduced after 72 h of incubation. The synthesized nanoparticles demonstrated a promising drug carrier for the treatment of SKOV-3 cells.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorNieciecka, Dorota
dc.contributor.authorKrysiński, Paweł
dc.contributor.authorPękała, Marek
dc.contributor.authorKrajewski, Michał
dc.contributor.authorŻelechowska-Matysiak, Kinga
dc.contributor.authorMajkowska-Pilip, Agnieszka
dc.contributor.authorOsial, Magdalena
dc.contributor.authorOlusegun, Sunday J.
dc.date.accessioned2024-01-26T09:26:20Z
dc.date.available2024-01-26T09:26:20Z
dc.date.issued2023
dc.description.financeNie dotyczy
dc.description.number12
dc.description.volume49
dc.identifier.doi10.1016/J.CERAMINT.2023.03.102
dc.identifier.issn0272-8842
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121278
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0272884223006867?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCeramics International
dc.relation.pages19851-19860
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enMagnetic hyperthermia
dc.subject.enIron oxides
dc.subject.enDrug delivery
dc.subject.enGadolinium
dc.subject.enStrontium
dc.titleSynthesis and characterization of Sr2+ and Gd3+ doped magnetite nanoparticles for magnetic hyperthermia and drug delivery application
dc.typeJournalArticle
dspace.entity.typePublication