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Differential Expression of Mitochondrial Biogenesis Markers in Mouse and Human SHH-Subtype Medulloblastoma

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dc.abstract.enMedulloblastoma is a brain tumor that arises predominantly in infants and children. It is the most common pediatric brain malignancy. Around 25\% of medulloblastomas are driven by constitutive activation of the Hedgehog signaling pathway. Hedgehog-driven medulloblastoma is often studied in the laboratory using genetic mouse models with overactive Hedgehog signaling, which recapitulate many of the pathological features of human Hedgehog-dependent tumors. However, we show here that on a molecular level the human and mouse HH-dependent MB are quite distinct, with human, but not mouse, tumors characterized by the presence of markers of increased oxidative phosphorylation and mitochondrial biogenesis. The latter suggests that, unlike for many other types of tumors, a switch to glycolytic metabolism might not be co-opted by human SHH-MB to perpetuate their survival and growth. This needs to be taken into consideration and could potentially be exploited in the design of therapies.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorNiewiadomski, Paweł
dc.contributor.authorWaschek, James A.
dc.contributor.authorŁastowska, Maria
dc.contributor.authorKarkucińska-Więckowska, Agnieszka
dc.date.accessioned2024-01-24T21:48:55Z
dc.date.available2024-01-24T21:48:55Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.identifier.doi10.3390/CELLS8030216
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104865
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofCells
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enmedulloblastoma Sonic hedgehog Shh oxidative phosphorylation mitochondria glycolysis Warburg effect gene expression mouse model
dc.titleDifferential Expression of Mitochondrial Biogenesis Markers in Mouse and Human SHH-Subtype Medulloblastoma
dc.typeJournalArticle
dspace.entity.typePublication