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Full-Length Computational Model of the SARS-CoV-2 Spike Protein and Its Implications for a Viral Membrane Fusion Mechanism

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cris.lastimport.scopus2024-02-12T20:29:37Z
dc.abstract.enThe SARS-CoV-2 virus has now become one of the greatest causes of infectious death and morbidity since the 1918 flu pandemic. Substantial and unprecedented progress has been made in the elucidation of the viral infection process in a short time; however, our understanding of the structure– function dynamics of the spike protein during the membrane fusion process and viral uptake remains incomplete. Employing computational approaches, we use full-length structural models of the SARS-CoV-2 spike protein integrating Cryo-EM images and biophysical properties, which fill the gaps in our understanding. We propose a membrane fusion model incorporating structural transitions associated with the proteolytic processing of the spike protein, which initiates and regulates a series of events to facilitate membrane fusion and viral genome uptake. The membrane fusion mechanism highlights the notable role of the S1 subunit and eventual mature spike protein uptake through the host membrane. Our comprehensive view accounts for distinct neutralizing antibody binding effects targeting the spike protein and the enhanced infectivity of the SARS-CoV-2 variant.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKulik, Marta
dc.contributor.authorNishima, Wataru
dc.date.accessioned2024-01-25T01:37:50Z
dc.date.available2024-01-25T01:37:50Z
dc.date.copyright2021-06-11
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number6
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3390/V13061126
dc.identifier.issn1999-4915
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107599
dc.identifier.weblinkhttps://www.mdpi.com/1999-4915/13/6/1126/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofViruses
dc.relation.pagesart.no. 1126
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enCoronavirus
dc.subject.enCOVID-19
dc.subject.enFusion mechanism
dc.subject.enMembrane fusion
dc.subject.enS protein
dc.subject.enSARS-CoV-2
dc.subject.enSpike protein
dc.subject.enViral entry
dc.titleFull-Length Computational Model of the SARS-CoV-2 Spike Protein and Its Implications for a Viral Membrane Fusion Mechanism
dc.typeJournalArticle
dspace.entity.typePublication