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Allostery in Its Many Disguises: From Theory to Applications

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dc.abstract.enAllosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, and metabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mechanisms are still poorly understood. A collection of contributions to a recent interdisciplinary CECAM (Center Européen de Calcul Atomique et Moléculaire) workshop is used here to provide an overview of the progress and remaining limitations in the understanding of the mechanistic foundations of allostery gained from computational and experimental analyses of real protein systems and model systems. The main conceptual frameworks instrumental in driving the field are discussed. We illustrate the role of these frameworks in illuminating molecular mechanisms and explaining cellular processes, and describe some of their promising practical applications in engineering molecular sensors and informing drug design efforts.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorHilser, Vincent J.
dc.contributor.authorLi, Jing
dc.contributor.authorKaranicolas, John
dc.contributor.authorBahar, Ivet
dc.contributor.authorHorovitz, Amnon
dc.contributor.authorMcLeish, Tom
dc.contributor.authorKozakov, Dima
dc.contributor.authorBolhuis, Peter G.
dc.contributor.authorChangeux, Jean-Pierre
dc.contributor.authorFaccioli, Pietro
dc.contributor.authorVreede, Jocelyne
dc.contributor.authorChebaro, Yassmine
dc.contributor.authorEberhardt, Jerome
dc.contributor.authorCecchini, Marco
dc.contributor.authorDejaegere, Annick
dc.contributor.authorStote, Roland H.
dc.contributor.authorHamm, Peter
dc.contributor.authorGkeka, Paraskevi
dc.contributor.authorYan, Le
dc.contributor.authorRavasio, Riccardo
dc.contributor.authorWyart, Matthieu
dc.contributor.authorBrito, Carolina
dc.contributor.authorPaci, Emanuele
dc.contributor.authorWodak, Shoshana J.
dc.contributor.authorPanecka-Hofman, Joanna
dc.contributor.authorBerezovsky, Igor N.
dc.contributor.authorOrioli, Simone
dc.contributor.authorDokholyan, Nikolay V.
dc.contributor.authorJang, Hyunbum
dc.contributor.authorTsai, Chung-Jung
dc.contributor.authorPadhorny, Dzmitry
dc.contributor.authorPizio, Antonella Di
dc.contributor.authorWade, Rebecca C.
dc.contributor.authorNussinov, Ruth
dc.contributor.authorNiv, Masha Y.
dc.contributor.authorRivalta, Ivan
dc.contributor.authorStock, Gerhard
dc.contributor.authorMcCammon, J. Andrew
dc.contributor.authorPalermo, Giulia
dc.date.accessioned2024-01-24T15:41:26Z
dc.date.available2024-01-24T15:41:26Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.number4
dc.description.volume27
dc.identifier.doi10.1016/J.STR.2019.01.003
dc.identifier.issn0969-2126
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100468
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0969212619300036?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.relation.ispartofStructure
dc.relation.pages566-578
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleAllostery in Its Many Disguises: From Theory to Applications
dc.typeJournalArticle
dspace.entity.typePublication