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Cytotoxicity Evaluation of Novel bis(2-aminoethyl)amine Derivatives

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dc.abstract.enSeven novel derivatives of bis(2-aminoethyl)amine were synthesized. For compounds 1 and 7 single crystals were isolated and X-ray diffraction experiments were done. Lipophilicity and drug likeness were calculated in the initial stage of research. All compounds were screened for their in vitro cytotoxic activity against a panel of human cancer cell lines, which is contrary to normal (HaCaT) cell lines, by using the MTT method. Studies were followed by lactate dehydrogenase assay, apoptotic activity, and interleukin-6 assay. Within the studied group, compound 6 showed the most promising results in all biological studies. The strongest influence in A549 cells was denoted for derivative 4, which inhibited interleukin release almost tenfold, as compared to the control.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDobrowolski, Michał
dc.contributor.authorOlejarz, Wioletta
dc.contributor.authorRoszkowski, Piotr
dc.contributor.authorSzulczyk, Daniel
dc.contributor.authorBielenica, Anna
dc.contributor.authorNapiórkowska, Mariola
dc.contributor.authorStruga, Marta
dc.date.accessioned2024-01-24T21:15:31Z
dc.date.available2024-01-24T21:15:31Z
dc.date.copyright2020-06-17
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number12
dc.description.versionFINAL_PUBLISHED
dc.description.volume25
dc.identifier.doi10.3390/MOLECULES25122816
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104100
dc.identifier.weblinkhttp://www.mdpi.com/
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMolecules
dc.relation.pages1-15 arto.no.2816
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enbis(2-aminoethyl)amine
dc.subject.enthiourea
dc.subject.entetrazole
dc.subject.encytotoxicity
dc.subject.encrystal structure ▼ Show Figures
dc.titleCytotoxicity Evaluation of Novel bis(2-aminoethyl)amine Derivatives
dc.typeJournalArticle
dspace.entity.typePublication