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STING Signaling in Cancer Cells: Important or Not?

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cris.lastimport.scopus2024-02-12T20:30:42Z
dc.abstract.enStimulator of interferon genes (STING) is an adaptor protein that plays an important role in the activation of type I interferons in response to cytosolic nucleic acid ligands. Recent evidence indicates involvement of the STING pathway in the induction of antitumor immune response. Therefore, STING agonists are now being extensively developed as a new class of cancer therapeutics. However, little is known about the consequences of activated STING-mediated signaling in cancer cells on the efficacy of the antitumor treatment. It has been shown that activation of the STING-dependent pathway in cancer cells can result in tumor infiltration with immune cells and modulation of the anticancer immune response. Understanding the function of STING pathway in cancer cells might provide important insights into the development of effective therapeutic strategies. This review focuses on the role of STING pathway in cancer cells, the largely unknown topic that has recently emerged to be important in the context of STING-mediated antitumor responses.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorNowis, Dominika
dc.contributor.authorSokołowska, Olga
dc.date.accessioned2024-01-26T08:10:34Z
dc.date.available2024-01-26T08:10:34Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.identifier.doi10.1007/S00005-017-0481-7
dc.identifier.issn0004-069X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/120732
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofArchivum Immunologiae et Therapiae Experimentalis
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleSTING Signaling in Cancer Cells: Important or Not?
dc.typeJournalArticle
dspace.entity.typePublication