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ExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions

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cris.lastimport.scopus2024-02-12T20:25:45Z
dc.abstract.enWe describe a new type of nucleotide-derived fluorescent probe designed for monitoring pyrophosphatase activity based on excimer-to-monomer transitions, called ExciTide. The nucleotides were designed with two self-interacting dye moieties and synthesised using copper-catalysed azide–alkyne cycloaddition click chemistry. We applied these probes for enzyme activity monitoring and inhibitor evaluation. Some of the probes permeated into living cells, yielding interesting prospects for future applications.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKasprzyk, Renata
dc.contributor.authorStrzelecka, Dominika
dc.contributor.authorSikorski, Paweł
dc.contributor.authorKopciał, Michał
dc.contributor.authorKowalska, Joanna
dc.contributor.authorWanat, Przemysław
dc.contributor.authorJemielity, Jacek
dc.date.accessioned2024-01-25T00:06:29Z
dc.date.available2024-01-25T00:06:29Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.volume70
dc.identifier.doi10.1039/C8CC04968H
dc.identifier.issn1359-7345
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106690
dc.identifier.weblinkhttps://pubs.rsc.org/en/content/articlehtml/2018/cc/c8cc04968h
dc.languageeng
dc.relation.ispartofChemical Communications
dc.relation.pages9773-9776
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleExciTides: NTP-derived probes for monitoring pyrophosphatase activity based on excimer-to-monomer transitions
dc.typeJournalArticle
dspace.entity.typePublication