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NAD(P)-dependent glucose dehydrogenase: Applications for biosensors, bioelectrodes, and biofuel cells

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cris.lastimport.scopus2024-02-12T20:18:03Z
dc.abstract.enThis review discusses the physical and chemical properties of nicotinamide redox cofactor dependent glucose dehydrogenase (NAD(P) dependent GDH) and its extensive application in biosensors and bio-fuel cells. GDHs from different organisms show diverse biochemical properties (e.g., activity and stability) and preferences towards cofactors, such as nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+). The (NAD(P)+) play important roles in biological electron transfer, however, there are some difficulties related to their application in devices that originate from their chemical properties and labile binding to the GDH enzyme. This review discusses the electrode modifications aimed at immobilising NAD+ or NADP+ cofactors and GDH at electrodes. Binding of the enzyme was achieved by appropriate protein engineering techniques, including polymerisation, hydrophobisation or hydrophilisation processes. Various enzyme-modified electrodes applied in biosensors, enzymatic fuel cells, and biobatteries are compared. Importantly, GDH can operate alone or as part of an enzymatic cascade, which often improves the functional parameters of the biofuel cell or simply allows use of cheaper fuels. Overall, this review explores how NAD(P)-dependent GDH has recently demonstrated high potential for use in various systems to generate electricity from biological sources for applications in implantable biomedical devices, wireless sensors, and portable electronic devices. Keywords:
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBilewicz, Renata
dc.contributor.authorStolarczyk, Krzysztof
dc.contributor.authorRogalski, Jerzy
dc.date.accessioned2024-01-25T13:23:30Z
dc.date.available2024-01-25T13:23:30Z
dc.date.issued2020
dc.description.financePublikacja bezkosztowa
dc.description.volume135
dc.identifier.doi10.1016/J.BIOELECHEM.2020.107574
dc.identifier.issn1567-5394
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113240
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S1567539419306401?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofBioelectrochemistry
dc.relation.pages107574
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.englucose
dc.subject.englucose dehydrogenase
dc.subject.enNAD(P)
dc.subject.enNAD
dc.subject.enbiosensor
dc.subject.enbiofuel cell
dc.titleNAD(P)-dependent glucose dehydrogenase: Applications for biosensors, bioelectrodes, and biofuel cells
dc.typeJournalArticle
dspace.entity.typePublication