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Determinants of the cytosolic turnover of mitochondrial intermembrane space proteins

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dc.abstract.enThe proteome of mitochondria comprises mostly proteins that originate as precursors in the cytosol. Before import into the organelle, such proteins are exposed to cytosolic quality control mechanisms. Multiple lines of evidence indicate a significant contribution of the major cytosolic protein degradation machinery, the ubiquitin-proteasome system, to the quality control of mitochondrial proteins. Proteins that are directed to the mitochondrial intermembrane space (IMS) exemplify an entire class of mitochondrial proteins regulated by proteasomal degradation. However, little is known about how these proteins are selected for degradation.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGlow, Edyta
dc.contributor.authorKhmelinskii, Anton
dc.contributor.authorKowalski, Lukasz
dc.contributor.authorKnop, Michael
dc.contributor.authorBRĄGOSZEWSKI, PIOTR
dc.contributor.authorChacińska, Agnieszka
dc.date.accessioned2024-01-24T21:38:15Z
dc.date.available2024-01-24T21:38:15Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.identifier.doi10.1186/S12915-018-0536-1
dc.identifier.issn1741-7007
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/104674
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofBMC Biology
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.en2018 Chacińska
dc.titleDeterminants of the cytosolic turnover of mitochondrial intermembrane space proteins
dc.typeJournalArticle
dspace.entity.typePublication