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Influence of Incorporation of Different dn-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Properties

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cris.lastimport.scopus2024-02-12T20:17:28Z
dc.abstract.enThree new compounds, namely [HL]2+[CuCl4]2−, [HL]2+[ZnCl4]2−, and [HL]2+[CdCl4]2− (where L: imipramine) were synthesized and their physicochemical and biological properties were thoroughly investigated. All three compounds form isostructural, crystalline systems, which have been studied using Single-Crystal X-ray diffraction analysis (SC-XRD) and Fourier-transform infrared spectroscopy (FTIR). The thermal stability was investigated using thermogravimetric analysis (TGA) and melting points for all compounds have been determined. Magnetic measurements were performed in order to study the magnetic properties of the compounds. The above mentioned techniques allowed us to comprehensively examine the physicochemical properties of the newly obtained compounds. The biological activity was investigated using the number of Zebrafish tests, as it is one of the most common models for studying the impact of newly synthesized compounds on the central nervous system (CNS), since this model is very similar to the human CNS.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorBanasiak, Robert
dc.contributor.authorRaducka, Anita
dc.contributor.authorFruziński, Andrzej
dc.contributor.authorBanasiak, Robert
dc.contributor.authorRogalewicz, Bartłomiej
dc.contributor.authorCzylkowska, Agnieszka
dc.contributor.authorWitkowski, Marcin
dc.contributor.authorCamargo, Bruno Cury
dc.contributor.authorCzylkowska, Agnieszka
dc.contributor.authorSzewczyk, Bernadeta
dc.contributor.authorPoleszak, Ewa
dc.contributor.authorCury, Bruno
dc.contributor.authorSzewczyk, Bernadeta
dc.contributor.authorKowalczyk, Joanna
dc.contributor.authorSzczesio, Małgorzata
dc.contributor.authorRogalewicz, Bartłomiej
dc.contributor.authorPoleszak, Ewa
dc.contributor.authorSzczytko, Jacek
dc.date.accessioned2024-01-25T04:13:49Z
dc.date.available2024-01-25T04:13:49Z
dc.date.copyright2021-11-29
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number23
dc.description.versionFINAL_PUBLISHED
dc.description.volume22
dc.identifier.doi10.3390/IJMS222312909
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/109251
dc.identifier.weblinkhttps://doi.org/10.3390/ijms222312909
dc.languageeng
dc.pbn.affiliationphysical sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages12909
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.encrystal structure
dc.subject.enFTIR spectroscopy
dc.subject.enthermogravimetric analysis
dc.subject.enimipramine
dc.subject.enmagnetic studies
dc.subject.encentral nervous system
dc.subject.enZebrafish
dc.titleInfluence of Incorporation of Different dn-Electron Metal Cations into Biologically Active System on Its Biological and Physicochemical Properties
dc.typeJournalArticle
dspace.entity.typePublication