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Recommendation on an updated standardization of serum magnesium reference ranges

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dc.abstract.enPurpose: Serum magnesium is the most frequently used laboratory test for evaluating clinical magnesium status. Hypomagnesemia (low magnesium status), which is associated with many chronic diseases, is diagnosed using the serum magnesium reference range. Currently, no international consensus for a magnesemia normal range exists. Two independent groups designated 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L) as the low cut-off point defining hypomagnesemia. MaGNet discussions revealed differences in serum magnesium reference ranges used by members’ hospitals and laboratories, presenting an urgent need for standardization. Methods: We gathered and compared serum magnesium reference range values from our institutions, hospitals, and colleagues worldwide. Results: Serum magnesium levels designating “hypomagnesemia” differ widely. Of 43 collected values, only 2 met 0.85 mmol/L as the low cut-off point to define hypomagnesemia. The remainder had lower cut-off values, which may underestimate hypomagnesemia diagnosis in hospital, clinical, and research assessments. Current serum magnesium reference ranges stem from “normal” populations, which unknowingly include persons with chronic latent magnesium deficit (CLMD). Serum magnesium levels of patients with CLMD fall within widely used “normal” ranges, but their magnesium status is too low for long-term health. The lower serum magnesium reference (0.85 mmol/L) proposed specifically prevents the inclusion of patients with CLMD. Conclusions: Widely varying serum magnesium reference ranges render our use of this important medical tool imprecise, minimizing impacts of low magnesium status or hypomagnesemia as a marker of disease risk. To appropriately diagnose, increase awareness of, and manage magnesium status, it is critical to standardize lower reference values for serum magnesium at 0.85 mmol/L (2.07 mg/dL; 1.7 mEq/L).
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMaj-Żurawska, Magdalena
dc.contributor.authorWolf, Federica
dc.contributor.authorYokota, Kuninobu
dc.contributor.authorWallace, Taylor C.
dc.contributor.authorTouyz, Rhian M.
dc.contributor.authorTeoh, Yee Ping
dc.contributor.authorSong, Yiqing
dc.contributor.authorShechter, Michael
dc.contributor.authorPourdowlat, Guitti
dc.contributor.authorNechifor, Mihai
dc.contributor.authorMerolle, Lucia
dc.contributor.authorMaier, Jeanette A.
dc.contributor.authorKraus, Anton
dc.contributor.authorKolisek, Martin
dc.contributor.authorKisters, Klaus
dc.contributor.authorKim, Dae Jung
dc.contributor.authorKahe, Ka
dc.contributor.authorIotti, Stefano
dc.contributor.authorEhrlich, Bodo von
dc.contributor.authorGletsu-Miller, Nana
dc.contributor.authorGuerrero-Romero, Fernando
dc.contributor.authorGamboa-Gomez, Claudia
dc.contributor.authorCostello, Rebecca B.
dc.contributor.authorCheng, Fu-Chou
dc.contributor.authorCampbell, Emily
dc.contributor.authorBarbagallo, Mario
dc.contributor.authorBaniasadi, Shadi
dc.contributor.authorMicke, Oliver
dc.contributor.authorElin, Ronald J.
dc.contributor.authorWest, Christina
dc.contributor.authorRosanoff, Andrea
dc.date.accessioned2024-01-25T18:57:56Z
dc.date.available2024-01-25T18:57:56Z
dc.date.issued2022
dc.description.financePublikacja bezkosztowa
dc.description.volume61
dc.identifier.doi10.1007/S00394-022-02916-W
dc.identifier.issn1436-6207
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/118035
dc.identifier.weblinkhttps://link.springer.com/content/pdf/10.1007/s00394-022-02916-w.pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofEuropean Journal of Nutrition
dc.relation.pages3697-3706
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enChronic latent magnesium deficit
dc.subject.enCLMD
dc.subject.enHypomagnesemia
dc.subject.enSerum magnesium
dc.subject.enSerum magnesium reference range
dc.titleRecommendation on an updated standardization of serum magnesium reference ranges
dc.typeJournalArticle
dspace.entity.typePublication