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Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

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cris.lastimport.scopus2024-02-12T20:04:11Z
dc.abstract.enMicrobiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world’s countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDziewit, Łukasz
dc.contributor.authorOdeh, Rasha
dc.contributor.authorO’Connell, Taylor
dc.contributor.authorNilsson, Anders S.
dc.contributor.authorNigro, Olivia D.
dc.contributor.authorNguyen, Nam-phuong
dc.contributor.authorMarr, Linsey C.
dc.contributor.authorMaritz, Julia M.
dc.contributor.authorLlagostera, Montserrat
dc.contributor.authorMonteiro, Silvia
dc.contributor.authorMolshanski-Mor, Shahar
dc.contributor.authorMcCann, Angela
dc.contributor.authorSantos, Ricardo
dc.contributor.authorRossi, Alessandro
dc.contributor.authorRice, Gillian A. O.
dc.contributor.authorReasor, Kim
dc.contributor.authorRaya, Raul
dc.contributor.authorRamírez-Rojas, Adán
dc.contributor.authorLisitsyna, Eugenia S.
dc.contributor.authorLipson, David
dc.contributor.authorLeigh, Steven R.
dc.contributor.authorKumaresan, Deepak
dc.contributor.authorKowalewski, Martin
dc.contributor.authorMirzaei, Mohammadali Khan
dc.contributor.authorHendriksen, Rene S.
dc.contributor.authorHead, Steven R.
dc.contributor.authorTrefault, Nicole
dc.contributor.authorIrwin, Mitchell T.
dc.contributor.authorIlina, Elena N.
dc.contributor.authorHyöty, Heikki
dc.contributor.authorHill, Colin
dc.contributor.authorNeve, Horst
dc.contributor.authorMuniesa, Maite
dc.contributor.authorMugisha, Lawrence
dc.contributor.authorAarestrup, Frank M.
dc.contributor.authorMorris, Megan
dc.contributor.authorZhernakova, Alexandra
dc.contributor.authorMoreira-Grez, Benjamin
dc.contributor.authorWagemans, Jeroen
dc.contributor.authorVinuesa, Pablo
dc.contributor.authorTyakht, Alexander V.
dc.contributor.authorVillagra, Nicolás
dc.contributor.authorIbekwe, MaryAnn Ugochi
dc.contributor.authorTwaddle, Alan
dc.contributor.authorTorres, Pedro J.
dc.contributor.authorStumpf, Rebecca
dc.contributor.authorWandro, Stephen
dc.contributor.authorStrain, Ronan
dc.contributor.authorStene, Lars C.
dc.contributor.authorStachler, Elyse N.
dc.contributor.authorShimashita, John
dc.contributor.authorQimron, Udi
dc.contributor.authorII, Aaron J. Prussin
dc.contributor.authorPiuri, Mariana
dc.contributor.authorOliver, Andrew
dc.contributor.authorRainetova, Petra
dc.contributor.authorQuan, Zhe-Xue
dc.contributor.authorDutilh, Bas E.
dc.contributor.authorZschach, Henrike
dc.contributor.authorZambrano, Maria M.
dc.contributor.authorWijmenga, Cisca
dc.contributor.authorWhiteson, Katrine L.
dc.contributor.authorWhiteley, Andy
dc.contributor.authorWhite, Bryan
dc.contributor.authorAlassaf, Abeer
dc.contributor.authorAhmadov, Gunduz
dc.contributor.authorMuñoz, Samuel L. Díaz
dc.contributor.authorDesnues, Christelle
dc.contributor.authorHaggerty, John M.
dc.contributor.authorGulino, Kristen M.
dc.contributor.authorGhedin, Elodie
dc.contributor.authorGarcia-Aljaro, Cristina
dc.contributor.authorFu, Jingyuan
dc.contributor.authorFranz, Charles
dc.contributor.authorEren, A. Murat
dc.contributor.authorTapia, German
dc.contributor.authorCortés, Pilar
dc.contributor.authorMuñoz, Alejandro Reyes
dc.contributor.authorNobrega, Franklin L.
dc.contributor.authorMcCarthy, David T.
dc.contributor.authorMazankova, Karla
dc.contributor.authorLavigne, Rob
dc.contributor.authorKurilshikov, Alexander
dc.contributor.authorFineran, Peter C.
dc.contributor.authorDoane, Michael P.
dc.contributor.authorIglesia, Rodrigo De la
dc.contributor.authorCuevas, Daniel A.
dc.contributor.authorCranfield, Mike
dc.contributor.authorKelley, Scott T.
dc.contributor.authorJunge, Randall E.
dc.contributor.authorJonge, Patrick A. de
dc.contributor.authorJofre, Juan
dc.contributor.authorCazares, Adrian
dc.contributor.authorJeffries, Thomas C.
dc.contributor.authorBrouns, Stan J. J.
dc.contributor.authorBibby, Kyle
dc.contributor.authorBarr, Jeremy J.
dc.contributor.authorMcNair, Katelyn
dc.contributor.authorCondeff, Tess
dc.contributor.authorCho, Gyu-Sung
dc.contributor.authorCazares, Daniel
dc.contributor.authorCarlton, Jane M.
dc.contributor.authorCantu, Vito Adrian
dc.contributor.authorBillings, Emma K.
dc.contributor.authorAsangba, Abigail
dc.contributor.authorAnton, Josefa
dc.contributor.authorCinek, Ondrej
dc.contributor.authorDinsdale, Elizabeth A.
dc.contributor.authorLevi, Kyle
dc.contributor.authorOhaeri, Maria
dc.contributor.authorNorman, Holly M.
dc.contributor.authorVega, Alejandro A.
dc.contributor.authorEdwards, Robert A.
dc.contributor.authorAziz, Ramy K.
dc.contributor.authorElwasila, Bashir Mukhtar
dc.contributor.authorDominy, Nathaniel J.
dc.contributor.authorDecewicz, Przemysław
dc.date.accessioned2024-01-25T02:07:26Z
dc.date.available2024-01-25T02:07:26Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.number10
dc.description.volume4
dc.identifier.doi10.1038/S41564-019-0494-6
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107967
dc.identifier.weblinkhttp://www.nature.com/articles/s41564-019-0494-6.pdf
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofNature Microbiology
dc.relation.pages1727-1736
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleGlobal phylogeography and ancient evolution of the widespread human gut virus crAssphage
dc.typeJournalArticle
dspace.entity.typePublication