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Extraction of triterpenic acids and phytosterols from apple pomace with supercritical carbon dioxide : impact of process parameters, modelling of kinetics, and scaling-up study

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dc.abstract.enApple pomace, a byproduct of juice production, is a rich source of bioactive compounds and nutrients. Supercritical fluid extraction was proposed as a method for a fast and selective extraction of hydrophobic compounds with a pharmaceutical potential from this matrix. Chromatographic analysis showed that the pomace contained significant amounts of such substances, the most abundant of them were ursolic acid, oleanolic acid, and β-sitosterol. The solubility was chosen as a primary factor for a selection of the extraction conditions; the best results were acquired for a temperature of 80 °C and a pressure of 30 MPa. The equation proposed by Chrastil was applied for the description of the impact of the process parameters on the solubility of the analytes; the obtained values of coefficients of determination were satisfactory, despite the fact that the equation was developed for binary systems. The extraction curves obtained during the experiments were used for the description of the process kinetics using the Broken plus Intact Cell model. The impact of the temperature, pressure, and flow rate of carbon dioxide on the mass transfer phenomena was investigated. The data obtained allowed the prediction of the extraction curve for the process conducted on the larger scale.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSzakiel, Anna
dc.contributor.authorSkąpska, Sylwia
dc.contributor.authorPączkowski, Cezary
dc.contributor.authorMarszałek, Krystian
dc.contributor.authorKowalska, Hanna
dc.contributor.authorJędrzejczak, Renata
dc.contributor.authorWoźniak, Łukasz
dc.date.accessioned2024-01-25T00:14:40Z
dc.date.available2024-01-25T00:14:40Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.volume23
dc.identifier.doi10.3390/MOLECULES23112790
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106877
dc.identifier.weblinkhttps://www.mdpi.com/1420-3049/23/11/2790
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofMolecules
dc.relation.pages1-15
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enβ-sitosterol
dc.subject.enbroken plus intact cell model
dc.subject.enMalus domestica
dc.subject.ensupercritical fluid extraction
dc.subject.enursolic acid
dc.titleExtraction of triterpenic acids and phytosterols from apple pomace with supercritical carbon dioxide : impact of process parameters, modelling of kinetics, and scaling-up study
dc.typeJournalArticle
dspace.entity.typePublication