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Gold electrodes and gold nanoparticles modified with sulphur-containing compounds and their selected applications

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dc.abstract.enGold electrodes and gold nanoparticles modified with sulphur-containing compounds and their selected applications.
dc.abstract.enGold nanoparticles (AuNPs) have been known since ancient times but have also been of great interest to scientists for over a century. Research in this field accelerated considerably at the beginning of the 21st century with the invention and development of new methods of synthesising a wide variety of one-, two- and three-dimensional structures. Desirable features that gold nanostructures possess, such as small size, various structural and optical properties, biocompatibility and ease of surface modification, make them very promising nanostructures and therefore they find applications in many fields. These applications may be more or less practical, but in all cases, they are exciting and promise new discoveries in many directions of human activity. Ease of functionalisation, among others with the use of sulphur-containing compounds (thiols, disulphides, dialkyl sulphides), results from the process of self-organisation, during which permanent, covalent Au-S bonds are formed. In this way, additional modifying substances with different properties can be attached to the surface of nanoparticles – electrochemically active compounds, e.g. ferrocene derivatives, therapeutics, e.g. drugs, fragments of genetic material, biological targeting substances, e.g. folic acid, substances that give stability (stabilisers), substances that change solubility or increase biocompatibility, e.g. PEG, substances that change optical properties, e.g. luminophors, etc. The possibilities in this field are actually limited only by the imagination of a scientist. It is worth mentioning here that permanent bonds can be created between the nanostructure and the modifying substance, as well as bonds that disintegrate under certain conditions of the surrounding environment, e.g. disintegration of conjugates under the influence of pH. The specific structure of nanoparticles and features such as a large surface to volume ratio, the presence of diverse crystallographic structures or a large number of edges with unsaturated coordination sites (sites of high activity) are the reason for their good electrochemical behaviour, including catalytic properties. The most frequently explored optical properties of gold nanoparticles depend primarily on factors such as size and shape, but also the composition of the nanostructure, surface charge, intermolecular interactions or the presence of adsorbed substances on their surface. It should be clearly emphasised here that the properties of nonspherical (asymmetrical) structures differ from those of spherical (highly symmetrical) structures. The most important optical property of anisotropic nanoparticles is the fact that they display multiple SPR signals in both visible and near infrared light, which makes them interesting and useful from a medical point of view (thermal therapy, bimodal therapies or imaging). In my research on gold nanoparticles, I particularly used properties such as the ease of functionalisation of their surface, favourable structural properties, unusual optical properties, and the fact that they are not toxic to cells / biological organisms. The aim of the doctoral thesis was to obtain various types of gold (nano)structures and to demonstrate their selected, important applications in solution and after immobilisation on gold or carbon electrodes.
dc.affiliation.departmentWydział Chemii
dc.contributor.authorOpuchlik, Lidia
dc.date.accessioned2021-04-30T10:43:47Z
dc.date.available2021-04-30T10:43:47Z
dc.date.defence2021-05-14
dc.date.issued2021-04-30
dc.description.promoterBilewicz, Renata
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/3930
dc.language.isoen
dc.rightsClosedAccess
dc.subject.enreduction
dc.subject.enoxidation
dc.subject.ensulphur
dc.subject.enoxygen
dc.subject.engold
dc.subject.ennanotriangle
dc.subject.ennanosphere
dc.subject.enanti-cancer therapy
dc.subject.ennanoparticles’ synthesis
dc.subject.encyclic voltammetry
dc.subject.endrug release
dc.subject.enAu-S bonding
dc.subject.ennanomaterial
dc.subject.enadsorption
dc.subject.ennanostructure
dc.subject.enPEG
dc.subject.enthiol
dc.subject.enself-assembly
dc.subject.enferrocenethiol
dc.subject.enin vitro cell studies
dc.subject.enspectroscopy
dc.subject.enmicroscopy
dc.subject.enrotating disc electrode
dc.subject.endoxorubicin
dc.subject.endrug carrier
dc.subject.enoxygen reduction reaction
dc.subject.enelectrochemistry
dc.subject.engold nanoparticle
dc.subject.plredukcja
dc.subject.plutlenianie
dc.subject.plsiarka
dc.subject.pltlen
dc.subject.plzłoto
dc.subject.plnanotrójkąt
dc.subject.plnanosfera
dc.subject.plterapia antyrakowa
dc.subject.plsynteza nanocząstek
dc.subject.plwoltamperometria cykliczna
dc.subject.pluwalnianie leku
dc.subject.plwiązanie Au-S
dc.subject.plnanomateriał
dc.subject.pladsorpcja
dc.subject.plnanostruktura
dc.subject.plPEG
dc.subject.pltiol
dc.subject.plsamoorganizacja
dc.subject.plferrocenotiol
dc.subject.plbadania in vitro na komórkach
dc.subject.plspektroskopia
dc.subject.plmikroskopia
dc.subject.plwirująca elektroda dyskowa
dc.subject.pldoksorubicyna
dc.subject.plnośnik leku
dc.subject.plreakcja redukcji tlenu
dc.subject.plelektrochemia
dc.subject.plnanocząstka złota
dc.titleGold electrodes and gold nanoparticles modified with sulphur-containing compounds and their selected applications
dc.title.alternativeZłote elektrody i nanocząstki złota modyfikowane związkami zawierającymi siarkę oraz ich wybrane zastosowania
dc.typeDoctoralThesis
dspace.entity.typePublication