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2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents

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cris.lastimport.scopus2024-02-12T20:16:52Z
dc.abstract.enThe ability of 2-deoxy-d-glucose (2-DG) to interfere with d-glucose metabolism demonstrates that nutrient and energy deprivation is an efficient tool to suppress cancer cell growth and survival. Acting as a d-glucose mimic, 2-DG inhibits glycolysis due to formation and intracellular accumulation of 2-deoxy-d-glucose-6-phosphate (2-DG6P), inhibiting the function of hexokinase and glucose-6-phosphate isomerase, and inducing cell death. In addition to glycolysis inhibition, other molecular processes are also affected by 2-DG. Attempts to improve 2-DG’s drug-like properties, its role as a potential adjuvant for other chemotherapeutics, and novel 2-DG analogs as promising new anticancer agents are discussed in this review.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSiwiak, Ewelina
dc.contributor.authorJaśkiewicz, Anna
dc.contributor.authorDomoradzki, Tomasz
dc.contributor.authorZieliński, R.
dc.contributor.authorSołtyka, Maja
dc.contributor.authorPriebe, A.
dc.contributor.authorBorowski, R.
dc.contributor.authorPriebe, W.
dc.contributor.authorFokt, I.
dc.contributor.authorPająk, Beata
dc.contributor.authorZiemniak, Marcin
dc.date.accessioned2024-01-24T15:35:41Z
dc.date.available2024-01-24T15:35:41Z
dc.date.copyright2019-12-29
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number1
dc.description.sdgGoodHealthAndWellBeing
dc.description.versionFINAL_PUBLISHED
dc.description.volume21
dc.identifier.doi10.3390/IJMS21010234
dc.identifier.issn1422-0067
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100046
dc.identifier.weblinkhttps://www.mdpi.com/1422-0067/21/1/234
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofInternational Journal of Molecular Sciences
dc.relation.pages234
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.en2-deoxy-d-glucose
dc.subject.en2-DG analogs
dc.subject.englioblastoma
dc.subject.enanticancer therapy
dc.title2-Deoxy-d-Glucose and Its Analogs: From Diagnostic to Therapeutic Agents
dc.typeJournalArticle
dspace.entity.typePublication