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Multi-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells

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dc.abstract.enCOVID-19 pandemic continues to remain a global health concern owing to the emergence of newer variants. Several multi-Omics studies have produced exten- sive evidence on host-pathogen interactions and potential therapeutic targets. Nonetheless, an increased understanding of host signaling networks regulated by post-translational modifications and their ensuing effect on the cellular dy- namics is critical to expanding the current knowledge on SARS-CoV-2 infections. Through an unbiased transcriptomics, proteomics, acetylomics, phosphoproteo- mics, and exometabolome analysis of a lung-derived human cell line, we show that SARS-CoV-2 Norway/Trondheim-S15 strain induces time-dependent alter-ations in the induction of type I IFN response, activation of DNA damage response, dysregulated Hippo signaling, among others. We identified interplay of phosphorylation and acetylation dynamics on host proteins and its effect on the altered release of metabolites, especially organic acids and ketone bodies. Together, our findings serve as a resource of potential targets that can aid in designing novel host-directed therapeutic strategies.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKandasamy, Richard K.
dc.contributor.authorKainov, Denis
dc.contributor.authorEspevik, Terje
dc.contributor.authorBjørås, Magnar
dc.contributor.authorNieminen, Anni I.
dc.contributor.authorGórna, Maria
dc.contributor.authorHagen, Lars
dc.contributor.authorKim, Hera
dc.contributor.authorSubbannayya, Yashwanth
dc.contributor.authorPinto, Sneha M.
dc.date.accessioned2024-01-25T13:12:40Z
dc.date.available2024-01-25T13:12:40Z
dc.date.copyright2022-12-28
dc.date.issued2023
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number1
dc.description.versionFINAL_PUBLISHED
dc.description.volume26
dc.identifier.doi10.1016/J.ISCI.2022.105895
dc.identifier.issn2589-0042
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113102
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S258900422202168X?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofiScience
dc.relation.pages105895
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleMulti-OMICs landscape of SARS-CoV-2-induced host responses in human lung epithelial cells
dc.typeJournalArticle
dspace.entity.typePublication