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Luminescent fac-[Re(CO)3(phen)] carboxylato complexes with non-steroidal anti-inflammatory drugs: synthesis and mechanistic insights into the in vitro anticancer activity of fac-[Re(CO)3phen)(aspirin)]

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dc.abstract.enFour fac-[Re(CO)3(phen)(L)] complexes with phen = 1,10-phenanthroline and L = a non-steroidal anti-inflammatory drug (NSAID) carboxylate ligand were obtained from the reaction of fac-[ReCl(CO)3(phen)] with ligands such as aspirin, (S)-(+)-ibuprofen, (S)-(+)-naproxen and indomethacin. Single-crystal X-ray diffraction analysis revealed a pseudo-octahedral coordination of the rhenium atom whereas the NSAID carboxylates act as monodentate ligands. The complexes show orange luminescence in polar solvents. Of the four compounds obtained, only fac-[Re(CO)3(phen)(aspirin)] exhibited activity against HeLa human cancer cells while it was inactive against the non-tumorigenic mouse L929 cell line. After uptake and dissociation in HeLa cells, the fac-[Re(CO)3(phen)(aspirin)] complex produces the luminescent fac-[Re(CO)3(phen)]+ cation, which predominantly accumulates in the mitochondria but does not penetrate to the nucleus, as shown by confocal microscopy. Once generated, the fac-[Re(CO)3(phen)]+ cation reversibly binds to hen egg white lysozyme (HEWL) while the aspirin ligand holds the ability to inhibit the COX-2 enzyme. The anticancer activity of the fac-[Re(CO)3(phen)(aspirin)] complex could be linked to ROS production, and cell cycle disturbance followed by triggering an apoptotic pathway of cell death.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKowalski, Konrad
dc.contributor.authorSchatzschneider, Ulrich
dc.contributor.authorStączek, Paweł
dc.contributor.authorSkiba, Joanna
dc.contributor.authorKowalczyk, Aleksandra
dc.contributor.authorCzerwieniec, Rafał
dc.contributor.authorBERNAŚ, TYTUS
dc.contributor.authorTrzybiński, Damian
dc.contributor.authorWoźniak, Krzysztof
dc.date.accessioned2024-01-25T05:29:51Z
dc.date.available2024-01-25T05:29:51Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.number2
dc.description.volume43
dc.identifier.doi10.1039/C8NJ05494K
dc.identifier.issn1144-0546
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/111598
dc.identifier.weblinkhttps://pubs.rsc.org/en/Content/ArticleLanding/2019/NJ/C8NJ05494K
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNew Journal of Chemistry
dc.relation.pages573-583
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleLuminescent fac-[Re(CO)3(phen)] carboxylato complexes with non-steroidal anti-inflammatory drugs: synthesis and mechanistic insights into the in vitro anticancer activity of fac-[Re(CO)3phen)(aspirin)]
dc.typeJournalArticle
dspace.entity.typePublication