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Ga(III) complex with morin for kidney cancer cell labelling

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dc.abstract.enThe formation of a complex between Ga(III) and morin (3,5,7,2′,4′-pentahydroxyflavone) was studied. UV–visible, infrared and mass spectroscopies were used to characterize the complex. The stoichiometric ratio for the reaction between metal ion and flavonoid was determined using the methods of Yoe–Jones and Job, which confirmed that a 1:1 Ga–morin complex was formed (estimated binding constant = 2.31 × 104 l mol−1). It was found that the coordination to Ga(III) occurs through the carbonyl oxygen atom and the 3-OH group of the morin molecule. According to developed conditions, complexation reaction with 68Ga was performed and the complex was used to label kidney cancer cells (CAKI-1, CAKI-2, ACHN and 786-O). The knowledge gained from this study should be useful for the development of new radiopharmaceuticals for diagnostic purposes containing 68Ga.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSentkowska, Aleksandra
dc.contributor.authorKopeć, Maciej
dc.contributor.authorKilian, Krzysztof
dc.contributor.authorPyrzyńska, Krystyna
dc.contributor.authorCheda, Łukasz
dc.date.accessioned2024-01-25T02:02:50Z
dc.date.available2024-01-25T02:02:50Z
dc.date.issued2017
dc.description.financeNie dotyczy
dc.description.number12
dc.description.volume31
dc.identifier.doi10.1002/AOC.3882
dc.identifier.issn0268-2605
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/107712
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofApplied Organometallic Chemistry
dc.relation.pagese3882
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enGa(III)-morin complex
dc.subject.enkidney cancer
dc.subject.enpositron emission tomography
dc.titleGa(III) complex with morin for kidney cancer cell labelling
dc.typeJournalArticle
dspace.entity.typePublication