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CC-BY - Uznanie autorstwaLocus-aware decomposition of gene trees with respect to polytomous species trees.
| cris.lastimport.scopus | 2024-02-12T20:06:10Z |
| dc.abstract.en | Background: Horizontal gene transfer (HGT), a process of acquisition and fxation of foreign genetic material, is an important biological phenomenon. Several approaches to HGT inference have been proposed. However, most of them either rely on approximate, non-phylogenetic methods or on the tree reconciliation, which is computationally intensive and sensitive to parameter values. Results: We investigate the locus tree inference problem as a possible alternative that combines the advantages of both approaches. We present several algorithms to solve the problem in the parsimony framework. We introduce a novel tree mapping, which allows us to obtain a heuristic solution to the problems of locus tree inference and duplication classifcation. Conclusions: Our approach allows for faster comparisons of gene and species trees and improves known algorithms for duplication inference in the presence of polytomies in the species trees. We have implemented our algorithms in a software tool available at https://github.com/mciach/LocusTreeInference. |
| dc.affiliation | Uniwersytet Warszawski |
| dc.contributor.author | Górecki, Paweł |
| dc.contributor.author | Ciach, Michał |
| dc.contributor.author | Muszewska, Anna |
| dc.date.accessioned | 2024-01-25T05:13:39Z |
| dc.date.available | 2024-01-25T05:13:39Z |
| dc.date.issued | 2018 |
| dc.description.accesstime | AT_PUBLICATION |
| dc.description.finance | Nie dotyczy |
| dc.description.version | FINAL_PUBLISHED |
| dc.description.volume | 13 |
| dc.identifier.doi | 10.1186/S13015-018-0128-1 |
| dc.identifier.issn | 1748-7188 |
| dc.identifier.uri | https://repozytorium.uw.edu.pl//handle/item/111434 |
| dc.identifier.weblink | https://almob.biomedcentral.com/articles/10.1186/s13015-018-0128-1 |
| dc.language | eng |
| dc.pbn.affiliation | computer and information sciences |
| dc.relation.ispartof | Algorithms for Molecular Biology |
| dc.relation.pages | 11 |
| dc.rights | CC-BY |
| dc.sciencecloud | nosend |
| dc.subject.en | Rank |
| dc.subject.en | Taxon |
| dc.subject.en | Ranked species tree |
| dc.subject.en | Speciation |
| dc.subject.en | Gene duplication |
| dc.subject.en | Gene loss |
| dc.subject.en | Horizontal gene transfer |
| dc.title | Locus-aware decomposition of gene trees with respect to polytomous species trees. |
| dc.type | JournalArticle |
| dspace.entity.type | Publication |