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TP53-Deficient Angiosarcoma Expression Profiling in Rat Model

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cris.lastimport.scopus2024-02-12T20:06:15Z
dc.abstract.enSarcomas are a heterogeneous group of malignant tumors, that develop from mesenchymal cells. Sarcomas are tumors associated with poor prognosis and expected short overall survival. Efforts to improve treatment efficacy and treatment outcomes of advanced and metastatic sarcoma patients have not led to significant improvements in the last decades. In the Tp53C273X/C273X rat model we therefore aimed to characterize specific gene expression pattern of angiosarcomas with a loss of TP53 function. The presence of metabolically active tumors in several locations including the brain, head and neck, extremities and abdomen was confirmed by magnetic resonance imaging (MRI) and positron emission tomography (PET) examinations. Limb angiosarcoma tumors were selected for microarray expression analysis. The most upregulated pathways in angiosarcoma vs all other tissues were related to cell cycle with mitosis and meiosis, chromosome, nucleosome and telomere maintenance as well as DNA replication and recombination. The downregulated genes were responsible for metabolism, including respiratory chain electron transport, tricarboxylic acid (TCA) cycle, fatty acid metabolism and amino-acid catabolism. Our findings demonstrated that the type of developing sarcoma depends on genetic background, underscoring the importance of developing more malignancy susceptibility models in various strains and species to simulate the study of the diverse genetics of human sarcomas.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorFiedorowicz, Michał
dc.contributor.authorSmyczyńska, Urszula
dc.contributor.authorGrieb, Paweł
dc.contributor.authorGuzowska, Magdalena
dc.contributor.authorFendler, Wojciech
dc.contributor.authorCheda, Łukasz
dc.contributor.authorCzarnecka, Anna
dc.contributor.authorSynoradzki, Kamil
dc.contributor.authorRogulski, Zbigniew
dc.contributor.authorWełniak-Kamińska, Marlena
dc.contributor.authorStrzemecki, Damian
dc.date.accessioned2024-01-26T11:04:32Z
dc.date.available2024-01-26T11:04:32Z
dc.date.copyright2020-06-10
dc.date.issued2020
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number6
dc.description.versionFINAL_PUBLISHED
dc.description.volume12
dc.identifier.doi10.3390/CANCERS12061525
dc.identifier.issn2072-6694
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/123625
dc.identifier.weblinkhttps://www.mdpi.com/2072-6694/12/6/1525
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCancers
dc.relation.pages1525
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enangiosarcoma
dc.subject.enTP53
dc.subject.enp53 TGEM Rat
dc.subject.enmicroarray analysis
dc.titleTP53-Deficient Angiosarcoma Expression Profiling in Rat Model
dc.typeJournalArticle
dspace.entity.typePublication