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Electrochemically Controlled Release from a Thin Hydrogel Layer

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dc.abstract.enIn this study, we present a thermoresponsive thin hydrogel layer based on poly(N-isopropylacrylamide), functionalized with β-cyclodextrin groups (p(NIPA-βCD)), as a novel electrochemically controlled release system. This thin hydrogel layer was synthesized and simultaneously attached to the surface of a Au quartz crystal microbalance (QCM) electrode using electrochemically induced free radical polymerization. The process was induced and monitored using cyclic voltammetry and a quartz crystal microbalance with dissipation monitoring (QCM-D), respectively. The properties of the thin layer were investigated by using QCM-D and scanning electron microscopy (SEM). The incorporation of β-cyclodextrin moieties within the polymer network allowed rhodamine B dye modified with ferrocene (RdFc), serving as a model metallodrug, to accumulate in the p(NIPA-βCD) layer through host–guest inclusion complex formation. The redox properties of the electroactive p(NIPA-βCD/RdFc) layer and the dissociation of the host–guest complex triggered by changes in the oxidation state of the ferrocene groups were investigated. It was found that oxidation of the ferrocene moieties led to the release of RdFc. It was crucial to achieve precise control over the release of RdFc by applying the appropriate electrochemical signal, specifically, by applying the appropriate potential to the electrode. Importantly, the electrochemically controlled RdFc release process was performed at a temperature similar to that of the human body and monitored using a spectrofluorimetric technique. The presented system appears to be particularly suitable for transdermal delivery and delivery from intrabody implants.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKarbarz, Marcin
dc.contributor.authorRomański, Jan
dc.contributor.authorJagleniec, Damian
dc.contributor.authorMarcisz, Kamil
dc.contributor.authorGwardys, Paulina
dc.date.accessioned2024-01-24T22:33:05Z
dc.date.available2024-01-24T22:33:05Z
dc.date.copyright2023-10-16
dc.date.issued2023
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number42
dc.description.versionFINAL_PUBLISHED
dc.description.volume15
dc.identifier.doi10.1021/ACSAMI.3C11786
dc.identifier.issn1944-8244
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/105967
dc.identifier.weblinkhttps://pubs.acs.org/doi/pdf/10.1021/acsami.3c11786
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofACS Applied Materials & Interfaces
dc.relation.pages49865-49873
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enelectrochemically controlled releasing system, thermosensitive thin hydrogel layer, N-isopropylacrylamide, β-cyclodextrins, inclusion complex
dc.titleElectrochemically Controlled Release from a Thin Hydrogel Layer
dc.typeJournalArticle
dspace.entity.typePublication