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Exome scale map of genetic alterations promoting metastasis in colorectal cancer

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cris.lastimport.scopus2024-02-12T20:21:53Z
dc.abstract.enApproximately 90\% of colorectal cancer (CRC) deaths are caused by tumors ability to migrate into the adjacent tissues and metastase into distant organs. More than 40 genes have been causally linked to the development of CRC but no mutations have been associated with metastasis yet. To identify molecular basis of CRC metastasis we performed whole-exome and genome-scale transcriptome sequencing of 7 liver metastases along with their matched primary tumours and normal tissue. Multiple, spatially separated fragments of primary tumours were analyzed in each case. Uniformly malignant tissue specimen were selected with macrodissection, for three samples followed with laser microdissection.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGoryca, Krzysztof
dc.contributor.authorKulecka, Maria
dc.contributor.authorPaczkowska, Katarzyna
dc.contributor.authorGrzelak, Marta
dc.contributor.authorMroz, Andrzej
dc.contributor.authorPaziewska, Agnieszka
dc.contributor.authorSkrzypczak, Magdalena
dc.contributor.authorGinalski, Krzysztof
dc.contributor.authorOstrowski, Jerzy
dc.contributor.authorMikula, Michał
dc.contributor.authorRutkowski, Andrzej
dc.contributor.authorDąbrowska, Michalina
dc.date.accessioned2024-01-25T00:07:05Z
dc.date.available2024-01-25T00:07:05Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.identifier.doi10.1186/S12863-018-0673-0
dc.identifier.issn1471-2156
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/106718
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofBMC Genetics
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleExome scale map of genetic alterations promoting metastasis in colorectal cancer
dc.typeJournalArticle
dspace.entity.typePublication