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Surface markers of cancer stem-like cells of ovarian cancer and their clinical relevance

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cris.lastimport.scopus2024-02-12T20:21:31Z
dc.abstract.enCancer stem-like cells (CSLCs) are defined as cancer cells with stem cell characteristics. Although CSLCs constitute no more than a few percent of the tumor mass, they play important roles in cancer chemo-resistance, metastasis and disease recurrence. Ovarian cancer (OC) is considered the most aggressive gynecological malignancy in which the role of CSLCs is of major significance, although it remains to be specified. The studies describing ovarian CSLC phenotype vary in the definition of the molecular pattern of expression of the main markers such as CD133, CD44, CD117, and CD24. Stem-like features of OC have been shown to correlate with the clinical course of the disease and permit diagnosis, prognosis and treatment outcome to be improved. Identification of CSLC markers could provide hallmarks which, related to the chemo-resistance of the disease, will facilitate treatment selection. This review describes recent advances in research on stem-like cell status in OC, mainly focusing on surface markers of CSLCs and their clinical relevance.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKieda, Claudine
dc.contributor.authorPurzycka-Olewiecka, J. Karolina
dc.contributor.authorLewicki, Sławomir
dc.contributor.authorCzarnecka, Anna
dc.contributor.authorLesyng, Bogdan
dc.contributor.authorSzczylik, Cezary
dc.contributor.authorWcisło, Gabriel
dc.contributor.authorKlemba, Aleksandra
dc.date.accessioned2024-01-26T09:25:07Z
dc.date.available2024-01-26T09:25:07Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number1A
dc.description.volume22
dc.identifier.doi10.5114/WO.2018.73885
dc.identifier.issn1428-2526
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121180
dc.identifier.weblinkhttps://www.termedia.pl/Surface-markers-of-cancer-stem-like-cells-of-ovarian-cancer-and-their-clinical-relevance,77,32001,1,1.html
dc.languageeng
dc.pbn.affiliationmedical sciences
dc.relation.ispartofWspółczesna Onkologia-Contemporary Oncology
dc.relation.pages48–55
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.encancer stem-like cells
dc.subject.enovarian cancer
dc.subject.ensurface markers
dc.subject.enprognosis
dc.titleSurface markers of cancer stem-like cells of ovarian cancer and their clinical relevance
dc.typeJournalArticle
dspace.entity.typePublication