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Synthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study

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cris.lastimport.scopus2024-02-12T20:19:47Z
dc.abstract.enIntroduction Intestinal parasitic infections are neglected diseases and, due to the increasing resistance of parasites to available drugs, they pose an increasing therapeutic challenge. Therefore, there is a great need for finding new compounds with antiparasitic activity. Objectives: In this work, new thiosemicarbazide and 1,2,4-triazole derivatives were synthesized and tested for their anthelmintic activity. Methods The synthesis was carried out by classical methods of organic chemistry. Anthelmintic activity tests were carried out in vitro (Rhabditis sp., Haemonchus contortus, Strongylidae sp.) in vitro (Heligmosomoides polygyrus/bakeri), and in silico analysis was performed.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorDoligalska, Maria
dc.contributor.authorBogucka-Kocka, Anna
dc.contributor.authorKocki, Janusz
dc.contributor.authorDawidowicz, Andrzej
dc.contributor.authorTypek, Rafał
dc.contributor.authorGranica, Sebastian
dc.contributor.authorReszka-Kocka, Patrycja
dc.contributor.authorTomczuk, Krzysztof
dc.contributor.authorStudzińska, Maria
dc.contributor.authorRoczeń-Karczmarz, Monika
dc.contributor.authorDemkowska-Kutrzepa, Marta
dc.contributor.authorBogucki, Jacek
dc.contributor.authorKhylyuk, Dmytro
dc.contributor.authorMakuch-Kocka, Anna
dc.contributor.authorWujec, Monika
dc.contributor.authorKołodziej, Przemysław
dc.date.accessioned2024-01-26T09:26:08Z
dc.date.available2024-01-26T09:26:08Z
dc.date.issued2023
dc.description.financeNie dotyczy
dc.identifier.doi10.1016/J.JARE.2023.07.004
dc.identifier.issn2090-1232
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121266
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/pii/S2090123223001960
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofJournal of Advanced Research
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enAnthelmintic therapy
dc.subject.enNematicidal compounds
dc.subject.enRhabditis sp.
dc.subject.enHaemonchus contortus
dc.subject.enStrongylidae sp.
dc.subject.enHeligmosomoides polygyrus/bakeri
dc.titleSynthesis and anthelmintic activity of novel thiosemicarbazide and 1,2,4-triazole derivatives: In vitro, in vivo, and in silico study
dc.typeJournalArticle
dspace.entity.typePublication