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Monosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs

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dc.abstract.enA new and convenient synthetic pathway was developed to produce monosubstituted cyclodextrins with high yields. Each of the β-cyclodextrin derivatives described in this work has an aromatic substituent connected with cyclodextrin core by a pH-sensitive hydrazone linker and a carbon chain. Carbon chains differ in lengths having one or three carbon atoms. The correlation between water solubility and linker length was determined using UV–Vis spectroscopy, while the dependence of hydrazone bond hydrolysis on the electrolyte pH was confirmed by cyclic voltammetry. The pH-dependent complex-formation ability between the hydrazone derivative of cyclodextrin and anthracycline drug was examined by square wave voltammetry. The significantly big solubility and the appropriate pH, at which the hydrolysis of the hydrazone bond occurs, make the newly synthesized derivatives attractive for pharmaceutical and medical applications.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorSadowska, Kamila
dc.contributor.authorKrzak, Agata
dc.contributor.authorMajdecki, Maciej
dc.contributor.authorŚwięch, Olga
dc.date.accessioned2024-01-25T12:54:08Z
dc.date.available2024-01-25T12:54:08Z
dc.date.copyright2018-09-06
dc.date.issued2019
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number1
dc.description.versionORIGINAL_AUTHOR
dc.description.volume93
dc.identifier.doi10.1007/S10847-018-0841-X
dc.identifier.issn1388-3127
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/112925
dc.identifier.weblinkhttps://doi.org/10.1007/s10847-018-0841-x
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Inclusion Phenomena
dc.relation.pages77-83
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enβ-Cyclodextrin · Monosubstituted cyclodextrin · pH-sensitivity · Drug delivery · Doxorubicin · Hydrazone bond
dc.titleMonosubstituted hydrazone β-cyclodextrin derivatives for pH-sensitive complex formation with aromatic drugs
dc.typeJournalArticle
dspace.entity.typePublication