Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

Doxorubicin conjugated to glutathione stabilized gold nanoparticles (Au-GSH-Dox) as an effective therapeutic agent for feline injection-site sarcoma - chick embryo chorioallantoic membrane study

Uproszczony widok
dc.abstract.enFeline injection-site sarcomas are malignant skin tumours with a high local recurrence rate, ranging from 14% to 28%. The treatment of feline injection-site sarcomas includes radical surgery, radiotherapy and/or chemotherapy. In our previous study it has been demonstrated that doxorubicin conjugated to glutathione-stabilized gold nanoparticles (Au-GSH-Dox) has higher cytotoxic effects than free doxorubicin for feline fibrosarcoma cell lines with high glycoprotein P activity (FFS1, FFS3). The aim of the present study was to assess the effectiveness of intratumoural injection of Au-GSH-Dox on the growth of tumours from the FFS1 and FFS3 cell lines on chick embryo chorioallantoic membrane. This model has been utilized both in human and veterinary medicine for preclinical oncological studies. The influence of intratumoural injections of Au-GSH-Dox, glutathione-stabilized gold nanoparticles and doxorubicin alone on the Ki-67 proliferation marker was also checked. We demonstrated that the volume ratio of tumours from the FFS1 and FFS3 cell lines was significantly (p < 0.01) decreased after a single intratumoural injection of Au-GSH-Dox, which confirms the positive results of in vitro studies and indicates that Au-GSH-Dox may be a potent new therapeutic agent for feline injection-site sarcomas.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorZabielska-Koczywąs, Katarzyna
dc.contributor.authorMieczkowski, Józef
dc.contributor.authorLechowski, Roman
dc.contributor.authorWójcik, Michał
dc.contributor.authorŻbikowski, Artur
dc.contributor.authorLewandowski, Wiktor
dc.contributor.authorKról, Magdalena
dc.contributor.authorDolka, Izabella
dc.date.accessioned2024-01-24T22:13:18Z
dc.date.available2024-01-24T22:13:18Z
dc.date.copyright2017-02-08
dc.date.issued2017
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number2
dc.description.versionFINAL_PUBLISHED
dc.description.volume22
dc.identifier.doi10.3390/MOLECULES22020253
dc.identifier.issn1420-3049
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/105288
dc.identifier.weblinkhttp://www.mdpi.com/1420-3049/22/2/253
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMolecules
dc.relation.pages253
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enin vivo study
dc.subject.endoxorubicin
dc.subject.engold nanoparticles
dc.subject.enCAM assay
dc.subject.enfeline injection-site sarcoma
dc.subject.enKi-67
dc.titleDoxorubicin conjugated to glutathione stabilized gold nanoparticles (Au-GSH-Dox) as an effective therapeutic agent for feline injection-site sarcoma - chick embryo chorioallantoic membrane study
dc.typeJournalArticle
dspace.entity.typePublication