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Beneficial influence of water-soluble PEG-functionalized C60 fullerene on human osteoblast growth in vitro

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cris.lastimport.scopus2024-02-12T20:12:40Z
dc.abstract.enThe purpose of this study was to make an initial assessment of new PEG (polyethylene glycol)-functionalized C60 fullerene derivative for potential bone tissue engineering applications. Thus, Fourier Transform Infrared spectroscopy analysis, thermogravimetric analysis, and cyclic voltammetry measurement were performed. Moreover, cell culture experiments in vitro were carried out using normal human osteoblasts. Cell viability and proliferation were evaluated using colorimetric 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) test as well as by fluorescent staining. It was demonstrated that resultant derivative possessed good solubility in water, high temperature stability, and retained favorable electron accepting properties of C60 fullerene core. Most important, new fullerene derivatives at low concentrations did not exhibit cytotoxic effect and supported osteoblast proliferation compared to control. Thanks to all mentioned properties of new PEG-functionalized C60 fullerene derivative, it seems that it could be used as a component of polymer-based bone scaffolds in order to enhance their biological properties.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGinalska, Grażyna
dc.contributor.authorKlimek, Katarzyna
dc.contributor.authorKaim, Andrzej
dc.contributor.authorPiotrowski, Piotr
dc.date.accessioned2024-01-24T18:34:22Z
dc.date.available2024-01-24T18:34:22Z
dc.date.copyright2021-03-22
dc.date.issued2021
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number6
dc.description.versionFINAL_PUBLISHED
dc.description.volume14
dc.identifier.doi10.3390/MA14061566
dc.identifier.issn1996-1944
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/102112
dc.identifier.weblinkhttps://www.mdpi.com/1996-1944/14/6/1566
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofMaterials
dc.relation.pages1566
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enfunctionalized fullerenes
dc.subject.enPEG
dc.subject.enwater solubility
dc.subject.encytotoxicity
dc.subject.encell proliferation
dc.subject.enosteoblasts
dc.titleBeneficial influence of water-soluble PEG-functionalized C60 fullerene on human osteoblast growth in vitro
dc.typeJournalArticle
dspace.entity.typePublication