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High genetic diversity of immunity genes in an expanding population of a highly mobile carnivore, the grey wolf Canis lupus , in Central Europe

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dc.abstract.enAim The aim of the study was to assess the effect of changes in population size and migration on variation in functional immunity genes in the previously bottlenecked population of the grey wolf, Canis lupus. Location Eastern/Central Europe: Poland, Czechia, Slovakia. Methods We genotyped 7 immunity genes: three MHC-DLA genes (dog leukocyte antigen) and four Toll-like receptor (TLR) genes among 130 wolves originating from three populations: two lowland (Baltic and Central European), and highland Carpathian. We contrasted the population structure in immunity genes with a neutral structure based on 13 microsatellites, and we analysed signatures of selection in the immunity loci. Results We found high overall genetic variance in immunity genes and no evidence for decreased diversity in the recently established populations. The population structure in immunity loci was weak, with pairwise FST lower than for neutral markers. Although the results of neutrality tests were not significant, we identified codons under selection, both positive and negative. Main Conclusions We demonstrated that despite recent population expansion which is expected to result in decreased genetic diversity, the diversity of immunity genes in the newly established wolf population is similar to those in the source population. This suggests that migrations do not cause allele loss in grey wolf. Signatures of selection on codon level, but not in tests using allele frequencies, suggest the contrasting effects of demography and selection.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorHulva, Pavel
dc.contributor.authorKłodawska, Monika
dc.contributor.authorHájková, Andrea
dc.contributor.authorNowak, Sabina
dc.contributor.authorNiedźwiedzka, Natalia
dc.contributor.authorBiedrzycka, Aleksandra
dc.contributor.authorSzewczyk, Maciej
dc.contributor.authorKloch, Agnieszka
dc.contributor.authorMysłajek, Robert
dc.contributor.authorJędrzejewska, Bogumiła
dc.date.accessioned2024-01-25T03:28:14Z
dc.date.available2024-01-25T03:28:14Z
dc.date.issued2021
dc.description.financeŚrodki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych
dc.identifier.doi10.1111/DDI.13360
dc.identifier.issn1366-9516
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108506
dc.identifier.weblinkhttps://onlinelibrary.wiley.com/doi/pdf/10.1111/ddi.13360
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofDiversity and Distributions
dc.relation.pages1-16
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enCanis lupus
dc.subject.enDLA
dc.subject.enfunctional genetic variance
dc.subject.engrey wolf
dc.subject.enimmunity genes
dc.subject.enMHC
dc.subject.enpopulation growth
dc.subject.enrange expansion
dc.subject.enToll-like receptors
dc.titleHigh genetic diversity of immunity genes in an expanding population of a highly mobile carnivore, the grey wolf Canis lupus , in Central Europe
dc.typeJournalArticle
dspace.entity.typePublication