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Redox-Responsive Degradable Microgel Modified with Superparamagnetic Nanoparticles Exhibiting Controlled, Hyperthermia-Enhanced Drug Release

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cris.lastimport.scopus2024-02-12T20:13:47Z
dc.abstract.enA novel degradable microgel based on poly(N-isopropylacrylamide) (pNIPA) cross-linked with N,N’-bisacryloylcystine (BISS) and containing superparam- agnetic iron oxide nanoparticles (SPION@CA) was synthesized by semi-batch precipitation polymerization and examined as a potential hyperthermia-en-hanced drug carrier. The pNIPA provided the microgel with temperature sen-sitivity, the BISS was responsible for degradation in the presence of glutathione (GSH) (an –S–S–bond reductor naturally present in cells), while the SPION@CA permitted remote control of temperature to improve drug release. The microgels exhibited volume phase transition temperature at ca. 34 °C, which is near the human body temperature, and were stable across a wide range of temperatures and ionic strengths, as well as in the blood plasma at 37 °C. It was found that the presence of SPION@CA in the polymer network of the microgels enabled the temperature to be increased up to 42 °C by an alternating magnetic field, and that increasing the temperature from 37 to 42 °C significantly enhanced the releasing of the anticancer drug doxorubicin (DOX). The highest DOX release (82%) was observed at pH 5, 42 °C, and in the presence of GSH, and the lowest (20%) at pH 7.4, 37 °C, and in the absence of GSH. MTT assay indicated that compared to free doxorubicin, the microgel particles loaded with doxorubicin have comparable cytotoxicity against MCF-7 cancer cells while being signifi- cantly less toxic to MCF-10A healthy cells.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKarbarz, Marcin
dc.contributor.authorKrysiński, Paweł
dc.contributor.authorRomański, Jan
dc.contributor.authorWałęka-Bargieł, Ewelina
dc.contributor.authorOsial, Magdalena
dc.contributor.authorMaćkiewicz, Marcin
dc.contributor.authorDagdelen, Serife
dc.date.accessioned2024-01-25T19:08:29Z
dc.date.available2024-01-25T19:08:29Z
dc.date.copyright2023-02-28
dc.date.issued2023
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number1
dc.description.sdgGoodHealthAndWellBeing
dc.description.versionFINAL_PUBLISHED
dc.description.volume58
dc.identifier.doi10.1007/S10853-023-08168-1
dc.identifier.issn0022-2461
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/118102
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Materials Science
dc.relation.pages4094–4114
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleRedox-Responsive Degradable Microgel Modified with Superparamagnetic Nanoparticles Exhibiting Controlled, Hyperthermia-Enhanced Drug Release
dc.typeJournalArticle
dspace.entity.typePublication