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Going to extremes - a metagenomic journey into the dark matter of life

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cris.lastimport.scopus2024-02-12T20:14:23Z
dc.abstract.enThe Virus-X—Viral Metagenomics for Innovation Value—project was a scientific expedition to explore and exploit uncharted territory of genetic diversity in extreme natural environments such as geothermal hot springs and deep-sea ocean ecosystems. Specifically, the project was set to analyse and exploit viral metagenomes with the ultimate goal of developing new gene products with high innovation value for applications in biotechnology, pharmaceutical, medical, and the life science sectors. Viral gene pool analysis is also essential to obtain fundamental insight into ecosystem dynamics and to investigate how viruses influence the evolution of microbes and multicellular organisms. The Virus-X Consortium, established in 2016, included experts from eight European countries. The unique approach based on high throughput bioinformatics technologies combined with structural and functional studies resulted in the development of a biodiscovery pipeline of significant capacity and scale. The activities within the Virus-X consortium cover the entire range from bioprospecting and methods development in bioinformatics to protein production and characterisation, with the final goal of translating our results into new products for the bioeconomy. The significant impact the consortium made in all of these areas was possible due to the successful cooperation between expert teams that worked together to solve a complex scientific problem using state-of-the-art technologies as well as developing novel tools to explore the virosphere, widely considered as the last great frontier of life.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKozłowski, Łukasz
dc.contributor.authorAhlqvist, Josefin
dc.contributor.authorAl-Karadaghi, Salam
dc.contributor.authorAltenbuchner, Joseph
dc.contributor.authorArsin, Hasan
dc.contributor.authorÁtlasson, Úlfur Áugúst
dc.contributor.authorBrandt, David
dc.contributor.authorMas, Thibaud
dc.contributor.authorCichowicz-Cieślak, Magdalena
dc.contributor.authorLutterman, Tobias
dc.contributor.authorCornish, Katy A S
dc.contributor.authorLorentsen, Steffen A
dc.contributor.authorCourtin, Jérémy
dc.contributor.authorDabrowski, Slawomir
dc.contributor.authorDahle, Håkon
dc.contributor.authorDjeffane, Samia
dc.contributor.authorDorawa, Sebastian
dc.contributor.authorDusaucy, Julia
dc.contributor.authorEnault, Francois
dc.contributor.authorFedøy, Anita-Elin
dc.contributor.authorFreitag-Pohl, Stefanie
dc.contributor.authorFridjonsson, Olafur H
dc.contributor.authorGaliez, Clovis
dc.contributor.authorGlomsaker, Eirin
dc.contributor.authorGuérin, Mickael
dc.contributor.authorGundesø, Sigurd E
dc.contributor.authorKalinowski, Jörn
dc.contributor.authorGudmundsdóttir, Elisabet E
dc.contributor.authorGudmundsson, Hördur
dc.contributor.authorKaczorowski, Tadeusz
dc.contributor.authorHåkansson, Maria
dc.contributor.authorJurczak-Kurek, Agata
dc.contributor.authorHenke, Christian
dc.contributor.authorJónsdóttir, Lilja Björk
dc.contributor.authorHelleux, Alexandra
dc.contributor.authorHenriksen, Jørn Remi
dc.contributor.authorHjörleifdóttir, Sigrídur
dc.contributor.authorHreggvidsson, Gudmundur O
dc.contributor.authorJasilionis, Andrius
dc.contributor.authorJónsdóttir, Ilmur
dc.contributor.authorJochheim, Annika
dc.contributor.authorWons, Ewa
dc.contributor.authorVincent, Jonathan
dc.contributor.authorWalse, Björn
dc.contributor.authorWang, Lei
dc.contributor.authorWatzlawick, Hildegard
dc.contributor.authorWelin, Martin
dc.contributor.authorWerbowy, Olesia
dc.contributor.authorZhang, Ruoshi
dc.contributor.authorVroling, Bas
dc.contributor.authorVanhalst, Justine
dc.contributor.authorBergh, Tom van den
dc.contributor.authorTourigny, Mathilde
dc.contributor.authorTerzian, Paul
dc.contributor.authorTarrant, Emma J
dc.contributor.authorSzadkowska, Monika
dc.contributor.authorSvensson, Anders
dc.contributor.authorStriberny, Bernd
dc.contributor.authorOverå, Katrine Stange
dc.contributor.authorSteinegger, Martin
dc.contributor.authorStefánsson, Sigmar Karl
dc.contributor.authorSteen, Ida H
dc.contributor.authorSolstad, Terese
dc.contributor.authorSöding, Johannes
dc.contributor.authorSkírnisdóttir, Sigurlaug
dc.contributor.authorSczyrba, Alexander
dc.contributor.authorSandaa, Ruth-Anne
dc.contributor.authorRóbertsdóttir, Tara
dc.contributor.authorReynisson, Birkir
dc.contributor.authorRay, Jessica L
dc.contributor.authorLiu, Ying
dc.contributor.authorLinares-Pastén, Javier
dc.contributor.authorLebrat, Julien
dc.contributor.authorLange, Joanna
dc.contributor.authorLanes, Olav
dc.contributor.authorKwiatkowska-Semrau, Karolina
dc.contributor.authorKrupovic, Mart
dc.contributor.authorPrangishvili, David
dc.contributor.authorPohl, Ehmke
dc.contributor.authorPlotka, Magdalena
dc.contributor.authorPétursdóttir, Sólveig K
dc.contributor.authorPerler, Francine
dc.contributor.authorPedersen, Cathrine
dc.contributor.authorOlgudóttir, Edda
dc.contributor.authorKarlsson, Eva Nordberg
dc.contributor.authorNdela, Eric Olo
dc.contributor.authorMorzywołek, Agnieszka
dc.contributor.authorMirdita, Milot
dc.contributor.authorMerré, William
dc.contributor.authorAevarsson, Arnthór
dc.contributor.authorKaczorowska, Anna-Karina
dc.contributor.authorAdalsteinsson, Björn Thor
dc.date.accessioned2024-01-25T02:21:52Z
dc.date.available2024-01-25T02:21:52Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.description.number12
dc.description.volume368
dc.identifier.doi10.1093/FEMSLE/FNAB067
dc.identifier.issn0378-1097
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108037
dc.languageeng
dc.pbn.affiliationcomputer and information sciences
dc.relation.ispartofFEMS Microbiology Letters
dc.relation.pages1-16
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.envirus
dc.subject.envirosphere
dc.subject.enarchaea
dc.subject.enmetagenomics
dc.subject.enbioprospecting
dc.subject.enthermophiles
dc.titleGoing to extremes - a metagenomic journey into the dark matter of life
dc.typeJournalArticle
dspace.entity.typePublication