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Multifunctional Nanoparticles Based on Iron Oxide and Gold-198 Designed for Magnetic Hyperthermia and Radionuclide Therapy as a Potential Tool for Combined HER2-Positive Cancer Treatment

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cris.lastimport.scopus2024-02-12T20:11:43Z
dc.abstract.enIron oxide nanoparticles are commonly used in many medical applications as they can be easily modified, have a high surface-to-volume ratio, and are biocompatible and biodegradable. This study was performed to synthesize nanoparticles designed for multimodal HER2-positive cancer treatment involving radionuclide therapy and magnetic hyperthermia. The magnetic core (Fe3O4) was coated with a gold-198 layer creating so-called core-shell nanoparticles. These were then further modified with a bifunctional PEG linker and monoclonal antibody to achieve the targeted therapy. Monoclonal antibody—trastuzumab was used to target specific breast and nipple HER2-positive cancer cells. The nanoparticles measured by transmission electron microscopy were as small as 9 nm. The bioconjugation of trastuzumab was confirmed by two separate methods: thermogravimetric analysis and iodine-131 labeling. Synthesized nanoparticles showed that they are good heat mediators in an alternating magnetic field and exhibit great specific binding and internalization capabilities towards the SKOV-3 (HER2 positive) cancer cell line. Radioactive nanoparticles also exhibit capabilities regarding spheroid degradation without and with the application of magnetic hyperthermia with a greater impact in the case of the latter. Designed radiobioconjugate shows great promise and has great potential for in vivo studies regarding magnetic hyperthermia and radionuclide combined therapy.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorRuszczyńska, Anna
dc.contributor.authorKrysiński, Paweł
dc.contributor.authorBilewicz, Aleksander
dc.contributor.authorMajkowska-Pilip, Agnieszka
dc.contributor.authorCiach, Tomasz
dc.contributor.authorPodgórski, Rafał
dc.contributor.authorŻuk, Michał
dc.date.accessioned2024-01-25T13:06:08Z
dc.date.available2024-01-25T13:06:08Z
dc.date.copyright2022-08-12
dc.date.issued2022
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financeŚrodki finansowe, o których mowa w art. 365 pkt. 2 ustawy
dc.description.number8
dc.description.versionFINAL_PUBLISHED
dc.description.volume14
dc.identifier.doi10.3390/PHARMACEUTICS14081680
dc.identifier.issn1999-4923
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/113071
dc.identifier.weblinkhttps://www.mdpi.com/1999-4923/14/8/1680/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofPharmaceutics
dc.relation.pages1680
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enNuclear medicine
dc.subject.enMagnetic hyperthermia
dc.subject.enTargeted therapy
dc.titleMultifunctional Nanoparticles Based on Iron Oxide and Gold-198 Designed for Magnetic Hyperthermia and Radionuclide Therapy as a Potential Tool for Combined HER2-Positive Cancer Treatment
dc.typeJournalArticle
dspace.entity.typePublication