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Hybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin

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cris.lastimport.scopus2024-02-12T20:13:05Z
dc.abstract.enCancer is one of the most common causes of death worldwide, thus new solutions in anticancer therapies are highly sought after. In this work, superparamagnetic iron oxide nanoparticles (SPIONs) conjugated with anticancer drugs are synthesized and investigated as potential magnetic drug nanocarriers for local drug delivery and mild magnetic hyperthermia. We have obtained a hybrid system loaded with holmium and anticancer drugs and thoroughly studied it with respect to the size, morphology, surface modifications and magnetic properties, and interactions with the model of biological membranes, cytotoxicity. We present that nanoparticles having a round shape and size 15 nm are successfully stabilized to avoid their agglomeration and modified with doxorubicin or epirubicin within a controlled way. The number of drugs loaded into the SPIONs was confirmed with thermogravimetry. The hybrid based on SPIONs was investigated in touch with model biological membranes within the Langmuir-Blodgett technique, and results show that modified SPION interacts effectively with them. Results obtained with magnetic hyperthermia and biological studies confirm the promising properties of the hybrid towards future cancer cell treatment.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorCelej, Joanna
dc.contributor.authorŻuk, Michał
dc.contributor.authorŻelechowska-Matysiak, Kinga
dc.contributor.authorMajkowska-Pilip, Agnieszka
dc.contributor.authorLis, Antoni
dc.contributor.authorOsial, Magdalena
dc.contributor.authorNieciecka, Dorota
dc.date.accessioned2024-01-25T03:31:17Z
dc.date.available2024-01-25T03:31:17Z
dc.date.copyright2021-04-01
dc.date.issued2021
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financeŚrodki finansowe przyznane na realizację projektu w zakresie badań naukowych lub prac rozwojowych
dc.description.number4
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3390/PHARMACEUTICS13040480
dc.identifier.issn1999-4923
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108768
dc.identifier.weblinkhttps://www.mdpi.com/1999-4923/13/4/480/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofPharmaceutics
dc.relation.pages480
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enSPIONs
dc.subject.enDoxorubicin
dc.subject.enEpirubicin
dc.subject.enMagnetic hyperthermia
dc.subject.enCytotoxicity
dc.subject.enLangmuir-Blodgett technique
dc.titleHybrid System for Local Drug Delivery and Magnetic Hyperthermia Based on SPIONs Loaded with Doxorubicin and Epirubicin
dc.typeJournalArticle
dspace.entity.typePublication