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Sulforaphane-conjugated selenium nanoparticles: towards a synergistic anticancer effect

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cris.lastimport.scopus2024-02-12T20:24:04Z
dc.abstract.enSulforaphane-modified selenium nanoparticles can be prepared in a simple aqueous-phase redox reaction through reduction of selenite with ascorbic acid. The sulforaphane molecules present in the reaction mixture adsorb on the nanoparticle surface, forming an adlayer. The resulting conjugate was examined with several physicochemical techniques, including microscopy, spectroscopy, x-ray diffraction, dynamic light scattering and zeta potential measurements. As shown in in vivo investigations on rats, the nanomaterial administered intraperitoneally is eliminated mainly in urine (and, to a lesser extent, in feces); however, it is also retained in the body. The modified nanoparticles mainly accumulate in the liver, but the basic parameters of blood and urine remain within normal limits. The sulforaphane-conjugated nanoparticles reveal considerable anticancer action, as demonstrated on several cancer cell cultures in vitro. This finding is due to the synergistic effect of elemental selenium and sulforaphane molecules assembled in one nanostructure (conjugate). On the other hand, the cytotoxic action on normal cells is relatively low. The high antitumor activity and selectivity of the conjugate with respect to diseased and healthy cells is extremely promising from the point of view of cancer treatment.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorOfiara, Karol
dc.contributor.authorMielczarek, Lidia
dc.contributor.authorWojciechowski, Piotr
dc.contributor.authorSzterk, Arkadiusz
dc.contributor.authorMazur, Maciej
dc.contributor.authorKaczyńska, Katarzyna
dc.contributor.authorKrug, Pamela
dc.contributor.authorAndrzejewski, Kryspin
dc.contributor.authorWiktorska, Katarzyna
dc.date.accessioned2024-01-26T09:21:23Z
dc.date.available2024-01-26T09:21:23Z
dc.date.issued2019
dc.description.financeNie dotyczy
dc.description.number6
dc.description.volume30
dc.identifier.doi10.1088/1361-6528/AAF150
dc.identifier.issn0957-4484
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121098
dc.identifier.weblinkhttps://iopscience.iop.org/article/10.1088/1361-6528/aaf150
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNanotechnology
dc.relation.pages65101
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enselenium
dc.subject.ennanoparticles
dc.subject.ensulforaphane
dc.subject.enanticancer agents
dc.subject.ensynergy
dc.titleSulforaphane-conjugated selenium nanoparticles: towards a synergistic anticancer effect
dc.typeJournalArticle
dspace.entity.typePublication