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Self-Supported Polymeric Ruthenium Complexes as Olefin Metathesis Catalysts in Synthesis of Heterocyclic Compounds

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cris.lastimport.scopus2024-02-12T20:24:05Z
dc.abstract.enNew ruthenium olefin metathesis catalysts containing N-heterocyclic carbene (NHC) connected by a linker tether to a benzylidene ligand were studied. Such obtained self-chelated Hoveyda–Grubbs type complexes existed in the form of an organometallic polymer but could still catalyze olefin metathesis after being dissolved in an organic solvent. Although these polymeric catalysts exhibited a slightly lower activity compared to structurally related nonpolymeric catalysts, they were successfully used in a number of ring-closing metathesis reactions leading to a variety of heterocyclic compounds, including biologically and pharmacologically related analogues of cathepsin K inhibitor and sildenafil (Viagra™). In the last case, a good solubility of a polymeric catalyst in toluene allowed the separation of the product from the catalyst via simple filtration
dc.affiliationUniwersytet Warszawski
dc.contributor.authorRajkiewicz, Adam
dc.contributor.authorGrela, Karol
dc.contributor.authorKajetanowicz, Anna
dc.date.accessioned2024-01-26T07:31:21Z
dc.date.available2024-01-26T07:31:21Z
dc.date.copyright2022-09-21
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number10
dc.description.versionFINAL_PUBLISHED
dc.description.volume12
dc.identifier.doi10.3390/CATAL12101087
dc.identifier.issn2073-4344
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/119592
dc.identifier.weblinkhttps://www.mdpi.com/2073-4344/12/10/1087/pdf
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofCatalysts
dc.relation.pages1087
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enolefin metathesis
dc.subject.enruthenium
dc.subject.enself-supported polymeric complex
dc.titleSelf-Supported Polymeric Ruthenium Complexes as Olefin Metathesis Catalysts in Synthesis of Heterocyclic Compounds
dc.typeJournalArticle
dspace.entity.typePublication