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Analysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland

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cris.lastimport.scopus2024-02-12T20:24:13Z
dc.abstract.enBackground and Objectives: Since vaccination against COVID-19 is available for over a year and the population of immunized individuals with autoimmune disorders is higher than several months before, an evaluation of safety and registered adverse events can be made. We conducted a large study of side effects following the COVID-19 vaccine among patients with multiple (MS) sclerosis treated with disease-modifying therapies (DMTs) and analyzed factors predisposing for particular adverse events. Methods: We gathered data of individuals with MS treated with DMTs from 19 Polish MS Centers, who reported at least one adverse event following COVID-19 vaccination. The information was obtained by neurologists using a questionnaire. The same questionnaire was used at all MS Centers. To assess the relevance of reported adverse events, we used Fisher's exact test, t-test, and U-Menn-Whutney test. Results: A total of 1,668 patients with MS and reports of adverse events after COVID-19 vaccination were finally included in the study. Besides one case marked as “red flag”, all adverse events were classified as mild. Pain at the injection site was the most common adverse event, with a greater frequency after the first dose. Pain at the injection site was significantly more frequent after the first dose among individuals with a lower disability (EDSS ≤2). The reported adverse events following immunization did not differ over sex. According to age, pain at the injection site was more common among individuals between 30 and 40 years old, only after the first vaccination dose. None of the DMTs predisposed for particular side effects. Conclusions: According to our findings, vaccination against COVID-19 among patients with MS treated with DMTs is safe. Our study can contribute to reducing hesitancy toward vaccination among patients with MS.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorZajkowska, Olga
dc.contributor.authorRościszewska-Żukowska, Iwona
dc.contributor.authorBartosik-Psujek, Halina
dc.contributor.authorTarasiuk, Joanna
dc.contributor.authorWnuk, Marcin
dc.contributor.authorMarona, Monika
dc.contributor.authorNowak, Klaudia
dc.contributor.authorSłowik, Agnieszka
dc.contributor.authorJamroz-Wiśniewska, Anna
dc.contributor.authorRejdak, Konrad
dc.contributor.authorLech, Beata
dc.contributor.authorPopiel, Małgorzata
dc.contributor.authorPerenc, Adam
dc.contributor.authorŚwiderek-Matysiak, Mariola
dc.contributor.authorSiger, Małgorzata
dc.contributor.authorCiach, Agnieszka
dc.contributor.authorWalczak, Agata
dc.contributor.authorJurewicz, Anna
dc.contributor.authorStasiołek, Mariusz
dc.contributor.authorKania, Karolina
dc.contributor.authorDyczkowska, Klara
dc.contributor.authorKalinowska-Łyszczarz, Alicja
dc.contributor.authorGalus, Weronika
dc.contributor.authorWalawska-Hrycek, Anna
dc.contributor.authorKrzystanek, Ewa
dc.contributor.authorChojdak-Łukasiewicz, Justyna
dc.contributor.authorUbysz, Jakub
dc.contributor.authorPokryszko-Dragan, Anna
dc.contributor.authorKapica-Topczewska, Katarzyna
dc.contributor.authorChorąży, Monika
dc.contributor.authorBazylewicz, Marcin
dc.contributor.authorMirończuk, Anna
dc.contributor.authorKulikowska, Joanna
dc.contributor.authorKochanowicz, Jan
dc.contributor.authorBiałek, Marta
dc.contributor.authorStolarz, Małgorzata
dc.contributor.authorKubicka-Bączyk, Katarzyna
dc.contributor.authorNiedziela, Natalia
dc.contributor.authorWarmus, Paweł
dc.contributor.authorAdamczyk-Sowa, Monika
dc.contributor.authorPodlecka-Piçtowska, Aleksandra
dc.contributor.authorNojszewska, Monika
dc.contributor.authorZakrzewska-Pniewska, Beata
dc.contributor.authorJasińska, Elżbieta
dc.contributor.authorZaborski, Jacek
dc.contributor.authorMilewska-Jȩdrzejczak, Marta
dc.contributor.authorPotemkowski, Andrzej
dc.contributor.authorZwiernik, Beata
dc.contributor.authorZwiernik, Jacek
dc.contributor.authorBrola, Waldemar
dc.contributor.authorKułakowska, Alina
dc.contributor.authorCzarnowska, Agata
dc.date.accessioned2024-01-24T16:29:39Z
dc.date.available2024-01-24T16:29:39Z
dc.date.copyright2022-06-14
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.versionFINAL_PUBLISHED
dc.description.volume13
dc.identifier.doi10.3389/FNEUR.2022.913283
dc.identifier.issn1664-2295
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/100629
dc.identifier.weblinkhttps://www.frontiersin.org/articles/10.3389/fneur.2022.913283/full
dc.languageeng
dc.pbn.affiliationeconomics and finance
dc.relation.ispartofFrontiers in Neurology
dc.relation.pagesart. id. 913283
dc.rightsCC-BY
dc.sciencecloudnosend
dc.subject.enmultiple sclerosis
dc.subject.envaccination
dc.subject.enSARS-CoV-2
dc.subject.enCOVID-19
dc.subject.enside effects
dc.titleAnalysis of Side Effects Following Vaccination Against COVID-19 Among Individuals With Multiple Sclerosis Treated With DMTs in Poland
dc.typeJournalArticle
dspace.entity.typePublication