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Influence of reaction conditions on the oxidation of thiol groups in model peptidomimetic oligoureas

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dc.abstract.enWorking with thiols is associated with the risk of unwanted oxidation reactions, which includes the formation of disulfides. Here, the use of short peptidomimetic oligoureas as a model system to study the influence of reaction conditions on the thiol oxidation process is described. The formation of disulfide bond is usually performed in aqueous solutions; in this study, it was shown that the oxidation reaction occurs also in organic medium. It was discovered that the rate of the oxidation reaction strongly depends on the type of solvent, which is the consequence of the change of the oxidant (air or DMSO), the temperature, and the presence (or absence) of base. The details reported here may help those working with thiols to find suitable conditions to control the oxidation behaviour in organic solvents, ensuring that ─SH groups either remain intact or form disulfide bonds as desired.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorPułka-Ziach, Karolina
dc.date.accessioned2024-01-25T04:13:58Z
dc.date.available2024-01-25T04:13:58Z
dc.date.issued2018
dc.description.financeNie dotyczy
dc.description.number8-9
dc.description.volume24
dc.identifier.doi10.1002/PSC.3096
dc.identifier.issn1075-2617
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/109264
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofJournal of Peptide Science
dc.relation.pagese3096
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.endisulfides
dc.subject.enDMSO oxidation
dc.subject.enoligoureas
dc.subject.enoxidation by air
dc.subject.enthiols
dc.titleInfluence of reaction conditions on the oxidation of thiol groups in model peptidomimetic oligoureas
dc.typeJournalArticle
dspace.entity.typePublication