Artykuł w czasopiśmie
Brak miniatury
Licencja
CC-BYCC-BY - Uznanie autorstwa
 

GPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models

Uproszczony widok
cris.lastimport.scopus2024-02-12T20:23:52Z
dc.abstract.enDue to the involvement of G protein-coupled receptors (GPCRs) in most of the physiological and pathological processes in humans they have been attracting a lot of attention from pharmaceutical industry as well as from scientific community. Therefore, the need for new, high quality structures of GPCRs is enormous. The updated homology modeling service GPCRM (http://gpcrm.biomodellab.eu/) meets those expectations by greatly reducing the execution time of submissions (from days to hours/minutes) with nearly the same average quality of obtained models. Additionally, due to three different scoring functions (Rosetta, Rosetta-MP, BCL::Score) it is possible to select accurate models for the required purposes: the structure of the binding site, the transmembrane domain or the overall shape of the receptor. Currently, no other web service for GPCR modeling provides this possibility. GPCRM is continually upgraded in a semi-automatic way and the number of template structures has increased from 20 in 2013 to over 90 including structures the same receptor with different ligands which can influence the structure not only in the on/off manner. Two types of protein viewers can be used for visual inspection of obtained models. The extended sortable tables with available templates provide links to external databases and display ligand–receptor interactions in visual form.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorLatek, Dorota
dc.contributor.authorFilipek, Sławomir
dc.contributor.authorMiszta, Przemysław
dc.contributor.authorJakowiecki, Jakub
dc.contributor.authorPasznik, Paweł
dc.contributor.authorSztyler, Agnieszka
dc.date.accessioned2024-01-25T02:22:19Z
dc.date.available2024-01-25T02:22:19Z
dc.date.copyright2018-05-21
dc.date.issued2018
dc.description.accesstimeAT_PUBLICATION
dc.description.financeNie dotyczy
dc.description.numberW1
dc.description.versionFINAL_PUBLISHED
dc.description.volume46
dc.identifier.doi10.1093/NAR/GKY429
dc.identifier.issn0305-1048
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108077
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofNucleic Acids Research
dc.relation.pagesW387-W395
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleGPCRM: a homology modeling web service with triple membrane-fitted quality assessment of GPCR models
dc.typeJournalArticle
dspace.entity.typePublication