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Gonadotropin-releasing hormone-Cu complex (Cu-GnRH) transcriptional activity in vivo in the female rat anterior pituitary gland

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dc.abstract.enAll examined genes responded to Cu-GnRH stimulation with increased transcriptional activity in a manner dependent on pulse frequency pattern. Increased expression of Nr5a1, Lhb, Nos1, Adcyap1, and Prkaca mRNA was observed solely in rats receiving the complex with frequency of two pulses/h over 5 h. Egr-1 transcription was up-regulated for both applied Cu-GnRH pulsatile patterns. The stimulatory effect of Cu-GnRH on gene transcription was dependent on both GnRH receptor and PAC-1 activation. In conclusion, obtained results indicate that Cu-GnRH complex is a GnRH analogue able to induce both IP3/ PKC and cAMP/PKA-dependent gonadotrope network gene transcription in vivo.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorKotarba, Grzegorz
dc.contributor.authorGajewska, Alina
dc.contributor.authorBiernacka, Katarzyna
dc.contributor.authorZielińska-Górska, Marlena
dc.date.accessioned2024-01-25T02:21:59Z
dc.date.available2024-01-25T02:21:59Z
dc.date.issued2020
dc.description.financeNie dotyczy
dc.description.volume156
dc.identifier.doi10.1016/J.BRAINRESBULL.2020.01.005
dc.identifier.issn0361-9230
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108048
dc.identifier.weblinkhttps://www.sciencedirect.com/science/article/abs/pii/S0361923019301042?via%3Dihub
dc.languageeng
dc.relation.ispartofBrain Research Bulletin
dc.relation.pages67-75
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.titleGonadotropin-releasing hormone-Cu complex (Cu-GnRH) transcriptional activity in vivo in the female rat anterior pituitary gland
dc.typeJournalArticle
dspace.entity.typePublication