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Testing enabling techniques for olefin metathesis reactions of lipophilic substrates in water as a diluent

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cris.lastimport.scopus2024-02-12T20:10:40Z
dc.abstract.enOlefin metathesis reactions of diverse polyfunctional substrates were conducted in water emulsions using two hydrophobic ruthenium catalysts in the presence of air. Instead of using surfactants to increase the efficiency of the metathesis reaction in water, ultrasound and microwave techniques were tested on a small-scale reaction, whereas conventional heating and mechanical stirring were effective enough to provide high conversion and selectivity on a larger scale. The developed conditions extend known protocols for the aqueous metathesis methodology, utilizing relatively low catalyst loadings and allowing for simple product isolation and purification. The established synthetic protocol was successfully adopted in the large-scale synthesis of a pharmaceutically related product – sildenafil (Viagra) derivative.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorGrela, Karol
dc.contributor.authorKajetanowicz, Anna
dc.contributor.authorDąbrowski, Michał
dc.contributor.authorNienałtowski, Tomasz
dc.contributor.authorPurohit, Vishal B.
dc.contributor.authorTyszka-Gumkowska, Agata
dc.date.accessioned2024-01-26T09:43:57Z
dc.date.available2024-01-26T09:43:57Z
dc.date.issued2022
dc.description.accesstimeAT_PUBLICATION
dc.description.financePublikacja bezkosztowa
dc.description.number4
dc.description.versionFINAL_PUBLISHED
dc.description.volume25
dc.identifier.doi10.1016/J.ISCI.2022.104131
dc.identifier.issn2589-0042
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/121735
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S2589004222004011?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationchemical sciences
dc.relation.ispartofiScience
dc.relation.pages104131
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleTesting enabling techniques for olefin metathesis reactions of lipophilic substrates in water as a diluent
dc.typeJournalArticle
dspace.entity.typePublication