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Visualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography

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dc.abstract.enWe employed electron cryo-tomography to visualize cytosolic ribosomes on the surface of mitochondria. Translation-arrested ribosomes reveal the clustered organization of the TOM complex, corroborating earlier reports of localized translation. Ribosomes are shown to interact specifically with the TOM complex, and nascent chain binding is crucial for ribosome recruitment and stabilization. Ribosomes are bound to the membrane in discrete clusters, often in the vicinity of the crista junctions. This interaction highlights how protein synthesis may be coupled with transport. Our work provides unique insights into the spatial organization of cytosolic ribosomes on mitochondria.EMBO Reports (2017) 18: 1786\textendash1800
dc.affiliationUniwersytet Warszawski
dc.contributor.authorChacińska, Agnieszka Małgorzata
dc.contributor.authorBrągoszewski, Piotr Mieczysław
dc.date.accessioned2024-01-26T11:49:30Z
dc.date.available2024-01-26T11:49:30Z
dc.date.issued2017
dc.description.accesstimeBEFORE_PUBLICATION
dc.description.financeNie dotyczy
dc.description.number10
dc.description.versionFINAL_PUBLISHED
dc.description.volume18
dc.identifier.doi10.15252/EMBR.201744261
dc.identifier.issn1469-221X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/124672
dc.identifier.weblinkhttp://embor.embopress.org/content/18/10/1786
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofEMBO Reports
dc.relation.pages1786-1800
dc.rightsCC-BY
dc.sciencecloudnosend
dc.titleVisualization of cytosolic ribosomes on the surface of mitochondria by electron cryo-tomography
dc.typeJournalArticle
dspace.entity.typePublication