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Immunomodulatory potential of nematodes against dendritic cells is dependent on intestinal inflamation

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dc.abstract.enThe mouse intestinal parasite Heligmosomoides polygyrus demonstrates adaptation to the inflammatory milieu as a result of colitis induced by dextran sulphate sodium (DSS). Nematodes from mice with colitis had different effects on dendritic cells than nematodes from mice without colitis. Immature JAWSII cells pre-exposed to L4 stage H. polygyrus from DSS-treated mice were adoptively transferred to mice with induced colitis. After two days, a higher disease activity index, macroscopic damage score and colon histology score were observed. MLN T cells isolated nine days after transfer demonstrated proinflammatory IFN-γ and IL-17 production. Transfer of JAWSII stimulated with male or female L4 larvae from a control invasion resulted in a slight improvement of colitis; in addition, dendritic cells exposed to H. polygyrus female L4 larvae, provoked migration of CD8+CD25+ T cells from MLN to the colon. Nematodes from an inflammatory environment changed cytokine production by dendritic cells. Inflammatory milieu changing nematode immunomodulatory activity affects dendritic cell functions, which offers new insight into the helminth-host relationship.
dc.affiliationUniwersytet Warszawski
dc.contributor.authorMaruszewska-Cheruiyot, Marta
dc.contributor.authorKrawczak, Katarzyna
dc.contributor.authorDonskow-Łysoniewska, Katarzyna
dc.contributor.authorMachcińska, Maja
dc.contributor.authorDoligalska, Maria
dc.date.accessioned2024-01-25T03:44:40Z
dc.date.available2024-01-25T03:44:40Z
dc.date.issued2021
dc.description.financePublikacja bezkosztowa
dc.description.volume115
dc.identifier.doi10.1016/J.DCI.2020.103879
dc.identifier.issn0145-305X
dc.identifier.urihttps://repozytorium.uw.edu.pl//handle/item/108981
dc.identifier.weblinkhttps://api.elsevier.com/content/article/PII:S0145305X20304341?httpAccept=text/xml
dc.languageeng
dc.pbn.affiliationbiological sciences
dc.relation.ispartofDevelopmental and Comparative Immunology
dc.relation.pages103879
dc.rightsClosedAccess
dc.sciencecloudnosend
dc.subject.enHeligmosomoides polygyrus
dc.subject.enDendritic cells
dc.subject.enAutoimmunity
dc.subject.enColitis
dc.titleImmunomodulatory potential of nematodes against dendritic cells is dependent on intestinal inflamation
dc.typeJournalArticle
dspace.entity.typePublication